摘要
Background Previous studies have suggested an association between vascular endothelial growth factor A(VEGFA)rs3025039 polymorphism and biliary atresia(BA).However,this conclusion is controversial and there is no published pooled evidence of this association.Methods This study was conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.The protocol was registered with PROSPERO(International Prospective Register of Systematic Reviews).A thorough search was performed on databases including PubMed,Embase,and Chinese Biomedical Database up to August 2020.This study included 846 cases of BA and 2821 controls concerning VEGFA rs3025039 polymorphism.We selected relevant studies based on the following inclusion criteria:(1)the study design was case-control and cohort and(2)the patients carried standard clinical diagnoses of BA,etc.The exclusion criteria were as follows:(1)patients with other related diseases,(2)lack of requisite information and(3)duplicate data.The OR(odd ratio)and the corresponding 95%CI(confidence interval)were calculated to estimate the association.Results This study on VEGFA rs3025039 polymorphism in the Chinese population included 846 cases and 2821 controls.The results showed that there was no significant association between rs3025039 and susceptibility to BA under four genetic models.The results of the subgroup analysis were similar to the overall results.Conclusions This meta-analysis shows that rs3025039 was not associated with susceptibility to BA in the Chinese population.Further validation may entail additional research.PROSPERO registration number CRD42020203812.
基金
This study received financial support from the Clinical Research Plan of SHDC(no SHDC2020CR2009A)
Shanghai Municipal Key Clinical Specialty(no shslczdzk05703)
National Natural Science Foundation of China(no 81770519,no 81771633,no 81873545,and no 81974059)
Science Foundation of Shanghai(no 18411969100 and no 19ZR1406600)
Children's National Medical Center(no EK1125180104,no EKYY20180204,no EK112520180211,and no EK112520180310).
