腹腔热灌注化疗联合DP方案在卵巢癌晚期患者治疗中的效果观察

Effect of Intraperitoneal Hyperthermic Perfusion Chemotherapy Combined With DP Regimen in the Treatment of Advanced Ovarian Cancer

目的探讨腹腔热灌注化疗(IHPC)联合多西他赛+顺铂(DP)方案治疗卵巢癌晚期患者的临床效果。方法按照治疗方法将80例卵巢癌晚期患者分为对照组与观察组,各40例。对照组采用DP方案治疗,在此基础上,观察组加用IHPC治疗。对比两组临床疗效,同时比较两组治疗前后血清肿瘤标志物水平[癌胚抗原(CEA)、糖链抗原125(CA125)]。结果治疗12周后,观察组临床总有效率较对照组高(P<0.05);治疗12周后,两组CEA、CA125水平较治疗前低,且观察组更低(P<0.05)。结论卵巢癌晚期患者采用IHPC联合DP方案治疗可有效提高临床疗效,降低血清肿瘤标志物。

Objective To investigate the clinical effect of intraperitoneal hyperthermic chemotherapy(IHPC)combined with docetaxel and cisplatin(DP)in the treatment of advanced ovarian cancer.Methods According to the treatment method,80 patients with advanced ovarian cancer were divided into control group and observation group,40 cases in each group.The control group was treated with DP regimen,and the observation group was treated with IHPC.The clinical efficacy was compared between the two groups,and the serum tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)]were compared between the two groups before and after treatment.Results After 12 weeks of treatment,the clinical total effective rate of the observation group was higher than that of the control group(P<0.05);after 12 weeks of treatment,the levels of CEA and CA125 in the two groups were lower than those before treatment,and the observation group was lower(P<0.05).Conclusion IHPC combined with DP regimen can effectively improve the clinical efficacy and reduce serum tumor markers in patients with advanced ovarian cancer.