多西环素治疗肺部感染发热患者感染指标的临床观察

Clinical Observation of Infection Index in Patients With Pulmonary Infection and Fever Treated With Doxycycline

目的探讨多西环素对肺部感染发热患者的感染指标的改善作用。方法收集诊断为肺部感染并且伴有明确发热症状患者共70例,随机分为试验组和对照组各35例。两组均给予一般支持治疗。对照组采用阿奇霉素抗感染治疗,试验组采用多西环素抗感染治疗。比较两组临床治疗有效率、发热症状消失时间、肺部感染指标水平以及用药期间不良反应发生情况。结果试验组治疗总有效率达94.29%,较对照组(85.71%)显著提高;发热持续时间及用药后体温降至正常时间均较对照组明显缩短(P<0.05);多西环素治疗后白细胞计数、CRP、降钙素原、白细胞介素-6指标改善较对照组更为显著(P<0.05);治疗过程中两组不良反应发生率差异无统计学意义(P>0.05)。结论多西环素治疗肺部感染伴发热患者既能迅速有效的退热,改善患者感染症状,还能明显降低血液中感染指标水平,疗效确切,安全性高,值得临床广泛推广。

Objective To investigate the effect of doxycycline on the improvement of infection index in patients with pulmonary infection and fever.Methods A total of 70 patients were randomly divided into the experimental group and the control group,35 patients in each group.Both groups were given general supportive treatment.The control group was treated with azithromycin and the experimental group was treated with doxycycline.The clinical treatment efficiency,the disappearance time of fever symptoms,the level of pulmonary infection indexes and the occurrence of adverse reactions during medication were compared between the two groups.Results The total effective rate of experimental group was 94.29%,which was significantly higher than that of control group(85.71%).The duration of fever and the time when the body temperature dropped to normal after medication were significantly shorter than those in the control group(P<0.05).WBC count,CRP,procalcitonin and interleukin-6 indexes were significantly improved after doxycycline treatment compared with control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P<0.05).Conclusion The treatment of doxycycline in patients with pulmonary infection with fever can not only rapidly and effectively reduce fever,improve the symptoms of infection,but also significantly reduce the level of infection indicators in blood,with definite efficacy and high safety,which is worthy of extensive clinical promotion.