摘要
Background:Clonorchiasis is attributed to the ingestion of raw freshwater fsh harboring Clonorchis sinensis.Morbid‑ity control is targeted through the administration of antihelminthics.This study modelled the cost yield indicated by efectiveness and utility of diferent treatment strategies against clonorchiasis.Methods:About 1000 participants were enrolled from each of 14 counties selected from four provincial-level administrative divisions namely Guangxi,Guangdong,Heilongjiang and Jilin in 2017.Fecal examination was adopted to detect C.sinensis infection,while behavior of ingesting raw freshwater fsh was enquired.Counties were grouped into four categories based on prevalence,namely low prevalence group(<1%),moderate prevalence group(1–9.9%),high prevalence group(10–19.9%)and very high prevalence group(≥20%),while population were divided into three subgroups,namely children aged below 14 years old,adult female and adult male both aged over 14 years old.The average of cost efectiveness indicated by the cost to treat single infected cases with C.sinensis and of cost utility indicated by the cost to avoid per disability-adjusted life years(DALYs)caused by C.sinensis infection was calculated.Comparisons were performed between three treatment schedules,namely individual treatment,massive and selec‑tive chemotherapy,in which diferent endemic levels and populations were considered.Results:In selective chemotherapy strategy,the cost to treat single infected case in very high prevalence group was USD 10.6 in adult male,USD 11.6 in adult female,and USD 13.2 in children.The cost increased followed the decrease of endemic level.In massive chemotherapy strategy,the cost per infected case in very high prevalence group was USD 14.0 in adult male,USD 17.1 in adult female,USD 45.8 in children,which were also increased when the endemic level decreased.In individual treatment strategy,the cost was USD 12.2 in adult male,USD 15.0 in adult female and USD 41.5 in children in very high prevalence group;USD 19.2 in adult male,USD 34.0 in adult female,and USD 90.1 in children in high prevalence group;USD 30.4 in adult male,USD 50.5 in adult female and over USD 100 in children in moderate prevalence group;and over USD 400 in any population in low prevalence group.As to cost utility,the difer‑ences by treatment strategies,populations and endemic levels were similar to those in cost efectiveness.Conclusions:Both cost efectiveness and cost utility indicators are highly impacted by the prevalence and popula‑tion,as well as the treatment schedules.Adults especially men in the areas with a prevalence over 10%should be prioritized,in which selective chemotherapy was best and massive chemotherapy was also cost efective.In moderate endemic areas,the yield is not ideal,but selective chemotherapy for adult male may also be adopted.In low endemic areas,all strategies were high costly and new strategies need to be developed.
