靶向癌蛋白调控Warburg效应的中医药研究进展

Research Progress of Traditional Chinese Medicine Targeting Oncoproteins to Regulate Warburg Effect

多数实体肿瘤很大程度上依赖有氧糖酵解来产生能量,从而适应其异质微环境。改变的能量代谢不仅为癌细胞提供ATP,还生成必需的代谢中间体,这些中间体在大分子的生物合成中起关键作用,以支持癌细胞增殖、侵袭和化学抗性。癌细胞代谢重编程受到几种癌蛋白(如HIF-1、ROS、Ras、Src、m TOR和Myc)的调控,对有氧糖酵解调控机制的深入理解有助于开发靶向糖酵解的治疗药物。中医药注重整体观念,中药多元化的成分使其具有多途径、多效应的特点,在治疗复杂而多因素的肿瘤综合征方面具有独特优势。本文现综述有关糖代谢中涉及的癌蛋白及中医药研究,旨在为抗糖酵解治疗提供新的靶点和突破口。

Most solid tumors rely heavily on aerobic glycolysis to generate energy to adapt to their heterogeneous microenvironment.Changing energy metabolism not only provides ATP for cancer cells,but also generates essential metabolic intermediates,which play a key role in the biosynthesis of macromolecules to support cancer cell proliferation,invasion and chemical resistance.The metabolic reprogramming of cancer cells is regulated by several cancer proteins(such as HIF-1,ROS,Ras,Src,mTOR and Myc).The in-depth understanding of the regulation mechanism of aerobic glycolysis is helpful to develop therapeutic drugs targeting glycolysis.Traditional Chinese medicine pays attention to the overall concept.The diversified components of traditional Chinese medicine make it have the characteristics of multi-channel and multi-effect,and have unique advantages in the treatment of complex and multi-factor tumor syndrome.This paper reviews the research on cancer proteins and traditional Chinese medicine related to glucose metabolism,aiming to provide new targets and breakthroughs for anti-diabetic treatment.