替格瑞洛对不稳定型心绞痛患者PCI术后缺血事件及炎症因子水平的影响

Effect of Ticagrelor on Ischemic Events and Inflammatory Factors in Patients with Unstable Angina Pectoris After PCI

目的研究替格瑞洛对不稳定型心绞痛患者PCI术后缺血事件及炎症因子水平的影响。方法选取2019年8月-2021年5月在我院行PCI术的84例不稳定型心绞痛患者为研究对象,采用随机数字表法分为对照组和观察组,各42例。对照组采用氯吡格雷治疗,观察组给予替格瑞洛治疗,比较两组炎症因子水平、缺血和出血事件发生率、血小板反应指数及不良反应发生情况。结果两组超敏C反应蛋白(hs-CRP)、白细胞(WBC)、中性粒细胞水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组缺血事件发生率为7.14%,低于对照组的19.04%,差异有统计学意义(P<0.05);观察组出血事件发生率为9.52%,低于对照组的21.43%,差异有统计学意义(P<0.05);两组血小板反应指数均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论替格瑞洛应用于不稳定型心绞痛患者PCI术后效果确切,可预防缺血和出血事件,降低炎症因子水平和血小板反应指数,应用安全性良好。

Objective To study the effect of ticagrelor on ischemic events and inflammatory factors in patients with unstable angina pectoris after PCI.Methods A total of 84 patients with unstable angina pectoris who underwent PCI in our hospital from August 2019 to May 2021 were selected as the research objects.They were divided into control group and observation group by random number table method,with 42 cases in each group.The control group was treated with clopidogrel,and the observation group was treated with ticagrelor.The levels of inflammatory factors,the incidence of ischemia and bleeding events,platelet response index and adverse reactions were compared between the two groups.Results The levels of hs-CRP,WBC and neutrophil in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).The incidence of ischemic events in the observation group was 7.14%,which was lower than 19.04%in the control group,and the difference was statistically significant(P<0.05).The incidence of bleeding events in the observation group was 9.52%,which was lower than 21.43%in the control group,and the difference was statistically significant(P<0.05).The platelet reaction index of the two groups was lower than that before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ticagrelor is effective in patients with unstable angina after PCI,which can prevent ischemia and bleeding events,reduce inflammatory factor levels and platelet response index,and has good application safety.