评价替吉奥联合索拉非尼对原发性肝癌患者不良情绪及睡眠质量的影响

To Evaluate the Effects of Tigio Combined with Sorafenib on Adverse Mood and Sleep Quality in Patients with Primary Liver Cancer

目的:评价替吉奥联合索拉非尼对原发性肝癌患者不良情绪及睡眠质量的影响。方法:选取2018年3月至2020年3月内蒙古医科大学附属人民医院收治的原发性肝癌患者88例作为研究对象,按照随机数字表法分为观察组和对照组,每组44例。采用匹兹堡睡眠指数量表(Pittsburgh Sleep Quality Index,PSQI)比较2组患者治疗前后睡眠质量的变化,采用抑郁自评量表(Self-rating Depression Scale,SDS)、焦虑自评量表(Self-rating Anxiety Scale,SAS)比较2组患者干预前后焦虑及抑郁状态的改善情况,观察2组患者在接受不同治疗方案下治疗总有效率的变化,比较2组患者治疗前后血清细胞因子表达的变化。结果:治疗后,观察组治疗总有效率显著高于对照组,观察组SAS评分、SDS评分、PSIQ评分、血清细胞因子表达均显著低于对照组,2组比较差异均有统计学意义(P<0.05)。结论:原发性肝癌患者给予替吉奥联合索拉非尼进行治疗,临床治疗效果较为突出,能够有效延长患者生存期,改善患者不良情绪,提高患者睡眠质量,可作为原发性肝癌治疗的首选方案,值得临床推广使用。

Objective:To evaluate the effects of tigio combined with sorafenib on adverse mood and sleep quality in patients with primary liver cancer.Methods:A total of 88 patients with primary liver cancer admitted to the Affiliated People′s Hospital of Inner Mongolia Medical University from March 2018 to March 2020 were selected as the research objects,and they were divided into observation group and control group according to the random number table method,with 44 patients in each group.Pittsburgh Sleep Quality Index(PSQI)was used to compare the changes of sleep quality in 2 groups before and after treatment,and Self-rating Depression Scale(SDS)and Self-rating Anxiety Scale(SAS)were used to compare the improvement of anxiety and depression before and after intervention,to observe the change of total effective rate in 2 groups receiving different treatment regiments,and to compare the change of serum cytokine expression in 2 groups before and after treatment.Results:After treatment,the total effective rate in the observation group was significantly higher than the control group,SAS score,the SDS score,PSIQ score and serum cytokine expression in the observation group were significantly lower than the control group.he differences were statistically significant(P<0.05).Conclusion:For patients with primary liver cancer,the clinical treatment effect is relatively outstanding,which can effectively prolong the survival period of patients,improve the adverse mood of patients,improve the quality of sleep of patients,which can be used as the first choice for the treatment of primary liver cancer,worthy of clinical promotion.