颅内动脉钙化与缺血性脑血管病的相关性研究

Analysis the correlation between intracranial arterial calcification and ischemic cerebrovascular disease

目的:探讨急性缺血性脑血管病患者颅内动脉钙化的分布规律及相关性。方法:回顾性收集2015年9月—2021年1月于青岛大学附属威海市立第二医院接受头颅CT平扫和头颅CT血管成像(CT angiography,CTA)检查的276例急性缺血性脑血管病患者的相关资料,采用Agatston法计算颅内动脉钙化积分,CT检测及评价脑腔隙灶。结果:检出颅内动脉钙化200例(72.46%),颈内动脉(internal carotid arteries,ICA)发生率为64.8%。颅内动脉钙化严重程度与腔隙灶相关(P<0.05),相关系数(rs)为0.285。颅内动脉钙化与腔隙灶相关性的优势比(OR)为3.5。结论:急性缺血性脑血管病患者中颅内动脉钙化发生率较高,以ICA为著。颅内动脉钙化与腔隙灶显著相关。运用CT量化颅内动脉钙化可作为缺血性脑血管病(ischemic cerebrovascular disease,ICVD)的一个潜在标志物,具有一定临床价值。

Objective This study aimed to investigate the distribution pattern of intracranial arterial calcification and its association with ischemic cerebrovascular disease(ICVD).Methods The data of 276 patients with acute ischemic cerebrovascular disease who underwent plain CT scan and CT angiography(CTA)in Weihai Municipal Second Hospital Affiliated to Qingdao University from September 2015 to January 2021 were collected retrospectively.The intracranial artery calcification score was calculated by Agatston method,and the cerebral lacunar foci were detected and evaluated by CT.Results Intracranial artery calcification was detected in 200(72.46%)cases;internal carotid arteries(ICA)had the highest prevalence(64.8%).The severity of intracranial lacunar calcification was related to the severity of intracranial lacunar calcification(P<0.05).The correlation coefficients(rs)were 0.285 for lacunes.The odds ratios(OR)of intracranial arterial calcification were 3.5 for lacunes.Conclusion Intracranial artery calcification is common in patients with ischemic cerebrovascular disease and the ICA is most frequently affected.Intracranial arterial calcifications might be associated with lacunes.Intracranial arterial calcification could act as a potential marker of ICVD.