血常规相关指标与全频型突发性聋预后的相关性研究

The Correlation between Blood-routine Parameters and Prognosis of All Frequency Sudden Sensorineural Hearing Loss

目的分析全频型突发性聋患者治疗前后血常规指标的变化及其与疗效的相关性。方法回顾性分析单侧全频型突发性聋患者102例的临床资料,根据疗效将患者分为有效组(59例)和无效组(43例),比较两组间治疗前后的血常规指标:白细胞(WBC)、中性粒细胞(NEUT)、单核细胞(MONO)、血小板(PLT)、淋巴细胞(LYM)、中性粒细胞/淋巴细胞比值(NLR)、单核细胞/淋巴细胞比值(MLR)、血小板/淋巴细胞比值(PLR)、平均血小板体积(MPV)、血小板分布宽度(PDW)和红细胞分布宽度(RDW)。结果与治疗前相比较,无效组治疗后RDW、NLR水平明显升高(P<0.05),有效组治疗后LYM水平明显升高(P<0.05)。治疗后无效组NLR、MLR、RDW水平明显高于有效组(P<0.05),LYM水平明显低于有效组(P<0.05);治疗后一个月时两组间治疗前后的PLR有差异,治疗无效组(13例)PLR高于有效组(38例)(P<0.05)。治疗后的NLR、MLR、PLR、RDW、LYM水平与听力恢复程度相关,回归分析示开始治疗的时间晚、治疗后高NLR水平是全频型突发性聋预后不良的独立危险因素。结论全频型突发性聋预后与开始治疗的时间、治疗后NLR、MLR、PLR、RDW、LYM水平相关。

Objective To investigate the changes of blood-routine parameters before and after treatment of all frequenery sudden sensorineural hearing loss(SSNHL).Methods Data from 102 patients with SSNHL at all frequencies were retrospectively analyzed.The patients were divided into the effective group(n=59)and the ineffective group(n=43)based on hearing improvement.Blood-routine parameters,including white blood cell(WBC),neutrophil(NEUT),monocyte(MONO),platelet(PLT),lymphocyte(LYM),neutrophil-to-lymphocyte ratio(NLR),monocyte-to-lymphocyte ratio(MLR),platelet-to-lymphocyte ratio(PLR),mean platelet volume(MPV),platelet distribution width(PDW)and red blood cell distribution width(RDW),were analyzed before and after treatment in both groups.Results After treatment,the levels of NLR and RDW in the ineffective group were significantly increased(P<0.05),and the level of LYM in the effective group was significantly increased(P<0.05).The levels of NLR,MLR and RDW tended to be higher in the ineffective group than those in the effective group after treatment,whereas that of LYM was lower in the ineffective group(P<0.05).The levels of PLR before and after treatment were significant different between groups at one-month follow-up(P<0.05).The levels of NLR,MLR,PLR,RDW,and LYM after treatment were associated with the improvement of hearing.Logistic regression analysis showed that late initiation of treatment and high level of NLR after treatment were independent risk factors for prognosis of all frequency SSNHL.Conclusion Prognosis of all frequency SSNHL is related to initiation time of treatment and the level of NLR,MLR,PLR,RDW and LYM after treatment.