肿瘤标志物评价不同化疗药物治疗晚期结肠癌的价值

Evaluation Value of Tumor Markers for Different Chemotherapy Agents in Treatment of Advanced Colon Cancer

目的:探讨血清癌胚抗原(CEA)、甲胎蛋白(AFP)、肿瘤相关抗原19-9(CA19-9)用于评价不同化疗药物治疗晚期结肠癌的价值。方法:收集2016年4月-2018年9月邵阳市中心医院收治的晚期结肠癌的患者62例作为研究对象,分为研究组和对照组,每组31例,两组患者基础抗肿瘤方案药物均给予奥沙利铂,研究组联合替吉奥治疗,对照组联合氟尿嘧啶静脉注射。对比两组抗肿瘤治疗前后CEA、AFP及CA19-9指标的变化,疗效及治疗过程中发生的不良反应。结果:两组患者治疗后的CEA、AFP及CA19-9指标均降低,且研究组低于对照组,差异有统计学意义(P<0.05)。研究组治疗后的总有效率高于对照组,差异有统计学意义(P<0.05)。研究组治疗期间的不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:奥沙利铂联合替吉奥在治疗晚期结肠癌的临床疗效更好,且治疗后的肿瘤标记物水平降低更为明显,不良反应发生率低。

Objective:To evaluate the value of serum carcinoembryonic antigen(CEA),alpha-fetoprotein(AFP),cancerassociated antigen 19-9(CA19-9)on evaluating different chemotherapy agents in the treatment of advanced colon cancer.Methods:A total of 62 patients with advanced colon cancer in Shaoyang Central Hospital from April 2016 to September 2018 were collected as the study subjects and divided into study group and control group,with 31 cases in each group.Oxaliplatin was used as the basic anti-tumor regimen drug for both study group and control group.The study group was treated with ticaggio and the control group was treated with fluorouracil intravenous injection.The changes of CEA,AFP and CA19-9 before and after antitumor treatment,therapeutic efficacy and adverse reactions occurred during treatment in the two groups were compared between the two groups.Results:The indexes of CEA,AFP and CA19-9 in the two groups decreased after treatment,and the study group was lower than the control group,the difference was statistically significant(P<0.05).The total effective rate of the study group was higher than that of the control group after treatment,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Oxaliplatin combined with ticaggio in the treatment of advanced colon cancer has better clinical efficacy.And after treatment,the levels of tumor markers decrease more significantly,and the incidence of adverse reactions is low.