吲哚里西啶生物碱5-epi-167B的合成研究

Study on the Synthesis of Indolicidine Alkaloid 5-epi-167B

报道一种简洁、高效的吲哚里西啶生物碱5-epi-167B的合成方法.该方法经过Michael加成反应、烯丙基三甲基硅烷参与的Schmidt重排反应,构建分子核心骨架,共6步反应,以12%总收率完成生物碱5-epi-167B高级中间体的合成.该方法在吲哚里西啶类生物碱的合成及其生物活性研究方面具有重要价值,可为相关研究提供参考.

This paper introduces a simple and efficient synthetic strategy of indolizidine alkaloid 5-epi-167B.In this synthesis strategy,the molecular core skeleton of the molecule is constructed with commercially purchased raw materials through Michael addition reaction and Schmidt rearrangement reaction with the participation of allyltrimethylsilane in 6 steps and 12%total yield to complete the synthesis of the advanced intermediate of alkaloid 5-epi-167B.This synthesis route is of great value in the synthesis and biological activity research of indolizidine alkaloids,and can be used as a reference for relevant research.