pH敏感载药系统应用于头颈部鳞状细胞癌治疗的研究进展

Research progress on pH⁃sensitive drug delivery systems in the treatment of head and neck squamous cell carcinoma

头颈部鳞状细胞癌(head and neck squamous cell carcinoma,HNSCC)是一种常见的肿瘤类型。目前针对头颈部鳞状细胞癌的治疗手段以手术治疗、放疗、化疗为主,然而这些治疗手段未能取得令人满意的治疗效果。pH敏感载药系统是利用环境pH的刺激产生相应的物理结构或化学性质变化,从而调控药物释放的一种环境刺激响应型载药系统,是载药系统研究领域的热点之一。目前在HNSCC治疗中使用pH敏感载药系统的药物包括阿霉素、紫杉醇类药物、5-氟尿嘧啶、顺铂等,在临床前研究中表现出良好的稳定性、肿瘤靶向性、释药可控性,极具临床转化价值。目前pH敏感载药系统仍面临粒径难以调控、载药量少、可能引起免疫反应等问题,因此pH敏感载药系统仍在不断改进中。本文从pH敏感载药系统用于HNSCC治疗的理论基础和研究进展两方面进行综述。

Head and neck squamous cell carcinoma(HNSCC)is a common tumor type.At present,surgical treatment,radiotherapy and chemotherapy are the main treatments for HNSCC,but these treatments have not achieved satisfactory results.The pH-sensitive drug delivery system is an environmental stimuli-responsive drug delivery system that utilizes the stimulation of environmental pH to produce corresponding changes in physical structure or chemical properties,thereby regulating drug release.This delivery system is the focus of the research field of drug delivery systems.At present,the drugs used in the pH-sensitive drug delivery system in the treatment of HNSCC include adriamycin,taxanes,5-fluorouracil,and cisplatin,and have shown good stability,tumor targeting,and drug release controllability in preclinical studies.This demonstrates great value in clinical transformation.At present,the pH-sensitive drug delivery system faces issues such as difficulty in particle size control,low drug loading,and possible immune response reactivity.Therefore,the pH-sensitive drug delivery system is still being improved.This article reviews the theoretical basis and research progress of the pH-sensitive drug delivery system in the treatment of HNSCC.