LRP5蛋白在纤维化疾病中的作用及机制研究进展

Research progress on the role and mechanism of LRP5 protein in fibrotic diseases.

纤维化(fibrosis)通常是指由于长期反复的炎症刺激、损伤,以及组织异常修复的启动,使成肌纤维细胞异常增殖和细胞外基质过度沉积,最终导致组织器官发生纤维化的病理过程。在全球范围内,组织纤维化仍是许多疾病致残、致死的主要原因之一。但是,目前纤维化疾病的发病机制尚未完全明确。低密度脂蛋白受体相关蛋白5 (LRP5)是定位于细胞膜表面的一种膜受体蛋白,其主要作用是作为Wnt/β-catenin信号通路的关键受体蛋白,参与经典Wnt/β-catenin信号通路的传导。已有的研究表明,LRP5在组织器官纤维化的发生发展中起着重要的作用。因此,本文旨在阐述LRP5在纤维化疾病中的作用及机制,为今后组织纤维化的防治提供理论依据。

Fibrosis is a pathological process that usually caused by long-term repeated inflammatory stimulation,injury,and the initiation of abnormal repair of tissue,resulting in abnormal proliferation of myofibroblasts and excessive deposition of extracellular matrix,and ultimately leading to the pathological process of fibrosis in tissues and organs.Worldwide,tissue fibrosis is still one of the major causes of disability and death from many diseases.However,the pathogenesis of fibrotic diseases has not been completely clarified.Low density lipoprotein receptor related protein 5(LRP5)is a membrane receptor protein located on the surface of cell membrane.Its main role is to act as a key receptor protein of the Wnt/β-catenin signaling pathway and it is involved in the transmission of the classical Wnt/β-catenin signaling pathway.Moreover,previous studies have shown that LRP5 plays an important role in the occurrence and development of tissue and organ fibrosis.Therefore,this review aims to explain the role and mechanism of LRP5 in fibrotic diseases and provide a theoretical basis for the prevention and treatment of tissue fibrosis in the future.