摘要
特发性膜性肾病(IMN)是一种自身免疫性足细胞病,是原发性肾小球疾病中导致终末期肾脏病(ESRD)的主要原因之一。近年来局灶节段性肾小球硬化(FSGS)的病理形态学特征对IMN患者预后的影响越来越受到人们的关注。笔者将基于这些病理改变的最新研究进展,阐述IMN合并FSGS病变的定义、分类及流行病学,分析IMN合并FSGS病变的发病机制、临床病理特点及其影响因素,阐明IMN合并FSGS病变的疗效及预后等,为IMN患者的治疗提供科学依据。
Idiopathic membranous nephropathy(IMN)is an autoimmune podocyte disease,and it is one of the leading causes of end-stage renal disease(ESRD)in primary glomerular disease.In recent years,IMN with focal segmental glomerulosclerosis(FSGS)has attracted much attention as a prognostic indicator of IMN patients.Based on the latest research progress of these pathological changes,this paper expounds the definition,classification,and epidemiology of IMN complicated with FSGS lesions,analyzes the pathogenesis,clinicopathological characteristics,and influencing factors,and clarifies the efficacy and prognosis,which provides a scientific basis for the treatment of patients with IMN.
作者
王晓玉(综述)
毕慧欣(审校)
WANG Xiao-yu;BI Hui-xin(Graduate School,Guilin Medical College,Guilin 541001,Guangxi,CHINA;Department of Nephrology,Hechi People's Hospital,Hechi 547000,Guangxi,CHINA;Department of Nephrology,Affiliated Hospital of Guilin Medical College,Guilin 541001,Guangxi,CHINA)
出处
《海南医学》
CAS
2022年第13期1732-1736,共5页
Hainan Medical Journal
基金
国家自然科学基金(编号:81960679)。
关键词
特发性膜性肾病
局灶节段性肾小球硬化
临床病理
疗效
预后
Idiopathic membranous nephropathy
Focal segmental glomerulosclerosis
Clinicopathological features
Efficacy
Prognosis
