壳聚糖蜂胶联合自体富血小板血浆复合材料在骨科非急性感染性创面中的临床应用

Clinical effect of chitosan propolis PRP composite on non-acute infectious wounds of orthopedic patients

目的 探讨壳聚糖蜂胶复合材料联合PRP(自体富血小板血浆)在骨科非急性感染性创面中的临床效果。方法 收集2020年1月至2021年10月,我院骨科收治的60例四肢非急性感染性创面患者,数字随机法分为A组(壳聚糖蜂胶治疗组20例)、B组(壳聚糖PRP治疗组20例)和C组(壳聚糖蜂胶PRP复合材料治疗组20例)三组,并评估治疗3、6、9、12 d后疼痛、生活质量评分,并对创面愈合时间、愈合面积、治疗前后炎性指标进行比较分析。结果 治疗前后三组患者疼痛、生活质量评分均具有明显改善(P <0.05);治疗后C组愈合时间明显短于A组和B组(P <0.05);治疗9 d后C组愈合面积优于A组和B组(P <0.05);治疗12 d后C组患者C反应蛋白、白细胞计数改善率明显优于A组和B组(P <0.05)。结论 PRP联合壳聚糖蜂胶复合材料在骨科非急性感染性创面中应用可有效抗菌,加快创面愈合,减轻患者疼痛感和提高患者生活质量。

Objective To investigate the clinical effect of PRP(autologous platelet-rich plasma)combined with chitosan probe composite on non-acute infectious wounds of orthopedic patients. Methods From September 2020 to July 2021,60 patients with non-acute infectious wounds on limbs admitted to the orthopedics department of our hospital were randomly divided by digital random method into groups A,B and C treated with chitosan propolis,chitosan PRP and chitosan propolis PRP composite,respectively,20 in each. The scores of pain,anxiety and quality of life after 3,6,9 and 12 days of treatment were evaluated. The wound healing time,healing area and inflammatory indexes before and after treatment were compared and analyzed. Results The scores of pain,anxiety and quality of life in three groups were significantly improved after treatment(P < 0.05). The healing time of group C was significantly shorter than that of group A and group B(P < 0.05). After 6 days treatment,the healing area of group C was significantly larger than those of group A and group B(P < 0.05). After 12 days treatment,the improvement rate of C-reactive protein and white blood cell count in group C was significantly higher than those in group A and group B(P < 0.05). Conclusion PRP combined with chitosan propolis composite material can effectively fight against bacteria,accelerate wound healing,relieve pain and improve the quality of life in orthopedic patients with non-acute infectious wounds.