不同年龄儿童维生素D营养状态研究

Nutritional status of vitamin D among children of different ages

目的 通过调查0~14岁儿童血清维生素D_(3)水平,为了解儿童维生素D营养水平及合理补充维生素D提供科学依据。方法 选取2020年在空军特色医学中心儿科健康体检的儿童1 736例,应用串联质谱法测定所有研究对象的血清25-(OH)D_(3),对不同季节。不同年龄儿童的血清25-(OH)D_(3)水平进行比较分析。结果 受检对象25-(OH)D_(3)平均水平为(28.908±11.372)ng/ml,整体不足,其中充足者占43.3%,不足者占34.3%,缺乏者占22.4%;25-(OH)D_(3)平均水平春季最高,水平充足;夏、秋、冬季均处于不足水平,冬季最低;<1岁,1岁~,2岁~各组25-(OH)D_(3)平均水平均处于充足水平,3岁~到7岁~各组25-(OH)D_(3)均处于不足水平,8岁~到13岁~各组均处于缺乏水平。结论 0~14岁儿童维生素D营养状态整体不足,存在明显差异,与年龄、季节有关,尚有相当一部分儿童维生素D营养状态处于不足或缺乏。

Objective To investigate the level of serum vitamin D_(3) in children aged 0 to 14 and to provide data for proper supplementation of vitamin D_(3) in children.Methods A total of 1736 children who underwent physical examinations in Air Force Special Medical Center in 2020 were selected.Serum 25-(OH)D_(3) levels of all the subjects were determined by high performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS).Results The average level of 25-(OH)D_(3) in these children was 28.908±11.372 ng/ml.The intakes of 25-(OH)D_(3) were adequate among 43.3%of these children,inadequate among 34.3%,and deficient among 22.4%.The 25-(OH)D_(3) level was the highest in spring,and the intakes were sufficient.In summer,autumn and winter,the intakes were insufficient,and the level was the lowest in winter.The 25-(OH)D_(3) levels were sufficient in the groups ages younger than 1 year old and under 1 to 2,insufficient in the groups aged 3 to 7,and deficient in the groups aged 8 to 13.Conclusion There is significant difference in nutritional status of vitamin D among children aged 0 to 14,which is related to age and season,and the intakes of vitamin D are insufficient or deficient among a large number of children.