肌少症与认知障碍的共同生物标志物研究

Research on common biomarkers of sarcopenia and cognitive impairment

肌少症及认知障碍是两大常见的老年综合征,两者互为因果,肌少症使认知障碍的患病风险增加,认知障碍也可引起肌少症,最终形成恶性循环关系。早期识别肌少症和认知障碍并对其进行干预,对改善老年患者的生活质量至关重要。而生物标志物较临床表型更早出现于机体。因此,本文从炎症、激素、营养及生长因子四个方面对肌少症和认知障碍的潜在共同生物标志物进行初步探讨,以期客观及时识别肌少症和认知障碍个体。

Sarcopenia and cognitive impairment,two common geriatric syndromes,have mutual causality.Sarcopenia increases the risk of cognitive impairment,and cognitive impairment can also cause sarcopenia,eventually developing into a vicious cycle.Early recognition and intervention of sarcopenia and cognitive impairment are crucial to improve the quality of life of the elderly patients.Biomarkers appear earlier in the body than clinical phenotypes.Therefore,this paper preliminarily discusses the potential common biomarkers of sarcopenia and cognitive impairment from four aspects,including inflammation,hormone,nutrition and growth factors,helping objective and timely identification of individuals with sarcopenia and cognitive impairment.