ADAMTS7基因rs3825807位点单核苷酸多态性与子痫前期遗传易感性关系

ASSOCIATION OF ADAMTS7 RS3825807 SINGLE NUCLEOTIDE POLYMORPHISM WITH GENETIC SUSCEPTIBILITY TO PRE-ECLAMPSIA

目的探讨含Ⅰ型血小板结合蛋白基序的解聚蛋白样金属蛋白酶7(ADAMTS7)基因rs3825807位点多态性与子痫前期(PE)遗传易感性的相关性。方法使用TaqMan探针实时荧光PCR技术,对山东地区706例PE病人(病例组)以及926例正常孕妇(对照组)的外周血DNA进行扩增,比较两组孕妇ADAMTS7基因rs3825807位点基因型及等位基因频率。结果病例组和对照组孕妇ADAMTS7基因rs3825807位点基因型及等位基因频率差异均无显著性(P>0.05);早发型、晚发型PE病人基因型及等位基因频率与对照组比较差异无统计学意义(P>0.05)。结论ADAMTS7基因rs3825807位点多态性与山东地区汉族人群PE的遗传易感性没有相关性。

Objective To investigate the relationship between single nucleotide polymorphism(SNP)of a disintegrin and metalloproteinase with thrombospondin motifs 7(ADAMTS7)locus rs3825807 and genetic susceptibility to pre-eclampsia(PE).Methods The peripheral blood DNA of 706 PE patients(patient group)and 926 healthy pregnant women(control group)in Shandong province were amplified by TaqMan probe real-time fluorescent quantitative PCR.The genotype and allele frequency of ADAMTS7 rs3825807 were compared between the two groups of pregnant women.Results There were no significant differences in the genotype and allele frequency of ADAMTS7 rs3825807 between PE patients and healthy pregnant women(P>0.05).There were no significant differences between patients with early and late onset PE and healthy pregnant women(P>0.05).Conclusion ADAMTS7 rs3825807 polymorphism is not associated with genetic susceptibility to PE in Han population living in Shandong province.