无症状人群中血压与颅内动脉粥样硬化性狭窄相关性

ASSOCIATION BETWEEN BLOOD PRESSURE AND INTRACRANIAL ATHEROSCLEROTIC STENOSIS IN ASYMPTOMATIC POPULATION

目的了解中国北方无症状人群中血压与颅内动脉粥样硬化性狭窄的相关性。方法本研究招募了192名患有无症状颅内动脉粥样硬化性狭窄(aICAS)的病人和740名未患有aICAS的健康体检者(阴性对照组),比较两组间血压水平差异,采用Logistic回归模型分析不同血压变量与aICAS之间的相关性。结果两组收缩压、脉压差、平均动脉压差异有统计学意义(U=61100~64280,P<0.05)。多元Logistic回归分析显示,平均动脉压升高(OR=1.174,95%CI=1.028~1.340,P=0.018)与aICAS的发生呈正相关,收缩压(α>0,P=0.005)和脉压差(α>0,P=0.002)与aICAS呈非线性关系,拐点分别为18.01、7.55 kPa。结论血压与aICAS显著相关,且收缩压、脉压差与aICAS呈非线性关系,脉压差过低与aICAS的高发生率相关。

Objective To investigate the association between blood pressure(BP)and intracranial atherosclerotic stenosis in the asymptomatic population in northern China.Methods This study recruited 192 patients with asymptomatic intracranial atherosclerotic stenosis(aICAS)and 740 individuals without aICAS who underwent physical examination(negative control group).The level of BP was compared between the two groups,and a logistic regression model was used to analyze the association between BP variables and aICAS.Results There were significant differences between the two groups in systolic blood pressure(SBP),pulse pressure(PP),and mean arterial pressure(MAP)(U=61100-64280,P<0.05).The multivariate Logistic regression analysis showed that elevated MAP(OR=1.174,95%CI=1.028-1.340,P=0.018)was positively associated with the onset of aICAS,and SBP(α>0,P=0.005)and PP(α>0,P=0.002)had a non-linear relationship with aICAS,with an inflection point of 18.01 kPa and 7.55 kPa,respectively.Conclusion BP is significantly associated with aICAS,and SBP and PP have a non-linear relationship with aICAS.In addition,extremely low PP is associated with a high incidence rate of aICAS.