中性粒细胞明胶酶相关脂质运载蛋白在代谢相关肾损伤中的应用价值分析

Application value of neutrophil gelatinase related lipid carrier protein in metabolism related renal injury

中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin, NGAL)作为一类新发现的脂肪细胞因子, 广泛存在于机体发生代谢异常时的病变组织细胞内。大量动物及临床试验证实, NGAL可在肝脏、肾脏、心脏、胰腺、前列腺及上皮细胞等多种组织中微表达, 在肥胖-炎症-代谢综合征及其引起的胰岛素抵抗、各种慢性肾病、心脑血管疾病、炎性反应及肿瘤等疾病中参与机体生理病理过程, 本文主要针对NGAL与代谢相关肾损伤的关系进行综述, 为临床的预防、早期诊断和治疗提供依据。

Neutrophil gelati-nase associated lipocalin(NGAL),as a newly discovered adipocytokines,widely exists in the cells of diseased tissues when metabolic abnormalities occur.A large number of animal and clinical trials have confirmed that NGAL can be expressed in trace amounts in various tissues such as liver,kidney,heart,pancreas,prostate and epithelial cells,and participate in the physiological and pathological process of obesity inflammation metabolism syndrome and its induced insulin resistance,various chronic kidney diseases,cardiovascular and cerebrovascular diseases,inflammatory response and tumors.This article mainly reviews the association between NGAL and metabolism related kidney injury,so as to provide basis for clinical prevention,early diagnosis and treatment.