肾功能正常的青年个体血浆脂联素水平与高血压的关系:汉中青少年高血压队列

Relationship between hypoadiponectinemia and hypertension in young individuals with normal renal function:Hanzhong adolescent hypertension study

目的基于汉中青少年高血压队列,探索肾功能正常的青年个体血浆脂联素水平与高血压患病的关系。方法以361名年龄为32~41岁肾功能正常的青年个体作为对象,并采集一般信息,测量血压、身高、体质量、心率等,测定空腹血糖、血脂、hs-CRP等生化指标,采用ELISA法测定血浆脂联素浓度;二元Logistic回归分析血浆脂联素水平与高血压患病的关系。结果高血压患者的血浆脂联素水平显著低于血压正常者[3.56(2.57~5.02)μg/mL vs.4.82(3.19~6.89)μg/mL,P=0.012]。偏相关分析显示,血浆脂联素水平与收缩压和舒张压均呈弱相关性(r=-0.155,P=0.003、r=-0.144,P=0.006)。二元Logistic回归分析显示,校正年龄、体质指数(BMI)和超敏C反应蛋白等混杂因素后,血浆脂联素位于性别特异性最低三分位者的高血压患病风险为最高三分位者的2.46倍(OR=2.46,95%CI:1.22~4.99)。结论低脂联素血症是肾功能正常的青年个体高血压患病的独立危险因素。

Objective To explore the relationship between plasma adiponectin levels and hypertension based on the Hanzhong adolescent hypertension cohort.Methods A total of 361 young individuals with normal renal function,aged 32 to 41 years old,were taken as the research subjects.We collected or measured data including general characteristics,blood pressure(BP),height,weight,pulse rate,and biochemistry indexes such as fasting glucose,blood lipid and plasma hs-CRP.The concentration of plasma adiponectin was determined by ELISA method.Binary logistic regression was performed to analyze the relationship between plasma adiponectin and hypertension.Results The plasma adiponectin level in patients with hypertension was significantly lower than that in normotensive patients[3.56(2.57-5.02))μg/mL vs.4.82(3.19-6.89)μg/mL,P=0.012].Partial correlation analysis showed a weak correlation of plasma adiponectin level with systolic BP and diastolic BP(r=-0.155,P=0.003 and r=-0.144,P=0.006).Binary logistic regression analysis showed that after adjusting for confounding factors such as age,BMI,and high-sensitivity C-reactive protein,the risk of hypertension was 2.46 times higher in patients with plasma adiponectin in the lowest gender-specific tertile than those in the highest tertile(OR=2.46,95%CI:1.22-4.99).Conclusion Hypoaponectinemia is an independent risk factor for hypertension in young individuals with normal renal function.