艾灸督脉组穴联合右佐匹克隆治疗卒中后失眠临床疗效及对神经递质的影响

Efficacy of the combination of moxibustion on the points of the Governor’s Vesseland Eszopiclone in the treatment of post-stroke insomnia and the effect of such treatments on Neurotransmitters

目的观察艾灸督脉组穴联合右佐匹克隆治疗卒中后失眠的临床疗效及探讨对神经递质血清伽马氨基丁酸(γ-GABA)、5-羟色胺(5-HT)水平的调节。方法将76例卒中后失眠患者按照随机原则分为治疗组(38例,脱落3例)、对照组(38例,脱落3例)。对照组予以右佐匹克隆3 mg,1次/天,治疗组在对照组基础上予以艾灸督脉组穴治疗,两组患者均治疗4周。比较两组患者治疗前后匹兹堡睡眠质量指数(PSQI)、日常生活能力评估(ADL)及血清γ-GABA、5-HT水平,并评定两组患者临床疗效。结果与治疗前相比,两组治疗后的PSQI得分均下降(P<0.05),治疗组较对照组下降更为显著(P<0.01);两组患者治疗后ADL评分较治疗前均增高(P<0.05),治疗组较对照组增高更为明显(P<0.05);失眠症疗效对比,治疗组高于对照组(P<0.05);治疗组提高血清γ-GABA、5-HT水平优于对照组(P<0.01)。结论艾灸督脉组穴联合右佐匹克隆治疗可有效改善卒中后失眠患者的临床症状,显著上调血清γ-GABA、5-HT水平,提高患者生活质量,临床疗效确切。

Objective To observe the clinical efficacy of the combination of moxibustion on the points of the Governor’s Vesseland Eszopiclone in the treatment of post-stroke insomnia and the regulating effect of such treatments on serumγ-GABA and 5-HT of neurotransmitters.Methods Seventy-six patients with post-stroke insomnia were randomly divided into the treatment group(38 patients,3 cases of shedding)and the control group(38 patients,3 cases of shedding).The control group was given 3 mg of dexzopiclone once a day.On the basis of the treatment for the control group,the treatment group was treated with moxibustion on the points of the Governor’s Vessel,and both groups were treated for 4 weeks.These two groups were compared in terms of Pittsburgh Sleep Quality Index(PSQI),Activity of Daily Living(ADL)and serumγ-GABA and 5-HT levels before and after treatment,and their clinical efficacy was evaluated.Results Compared with those before treatment,PSQI scores in both groups decreased after treatment(P<0.05),and the decrease in the treatment group was more significant than that in the control group(P<0.01).Compared with those before treatment,the ADL score in two groups increased after treatment(P<0.05),and the increase in the treatment group was more significant than that in the control group(P<0.05).The curative effect for insomnia in the treatment group was higher than that in the control group(P<0.05).The improvement ofγ-GABA and 5-HT in the treatment group was more significant than that in the control group(P<0.01).Conclusion The combination of moxibustion on the points of the Governor’s Vesseland Eszopiclone can effectively improve the clinical symptoms of patients with post-stroke insomnia.Such a treatment can also significantly up-regulate serumγ-GABA and 5-HT levels,and improve the quality of life of patients.Its clinical efficacy is definite.