IL-2在系统性红斑狼疮中的作用研究进展

Advances on role of IL-2 in systemic lupus erythematosus

白细胞介素2(IL-2)促进调节性T细胞(Treg)和B淋巴细胞活化增殖并参与体液免疫与细胞免疫应答,介导细胞毒性T细胞(cTc)、自然杀伤细胞(NK)、淋巴因子激活的杀伤细胞(LAK)等的分化,在抗感染与肿瘤免疫中发挥重要作用。近年研究发现IL-2缺乏引起Treg-IL-2轴紊乱破坏外周免疫耐受稳态,在系统性红斑狼疮(SLE)等多种自身免疫性疾病的发病机制中起重要作用,同时小剂量IL-2治疗SLE在国内外均取得良好疗效。本文就IL-2在SLE发病机制及治疗的研究进展进行综述。

Interleukin-2(IL-2)promotes the activation and proliferation of regulatory T cell(Treg)and B lymphocytes,participating in humoral and cellular immune responses and mediating the differentiation of cytotoxic T cell(cTc),natural killer cell(NK)and lymphokine-activated killer cell(LAK),and plays an important role in anti-infection and anti-tumor immune response. In recent years,various studies had confirmed the disorder of Treg-IL-2 axis caused by IL-2 deficiency,which destroys the homeostasis of peripheral immune tolerance and plays an important role in the pathogenesis of many autoimmune diseases such as systemic lupus erythematosus(SLE). Domestic and foreign studies on the treatment of low-dose IL-2 for patients with SLE have achieved significant clinical efficacy and good safety. This article reviews the research progress of IL-2 in the pathogenesis and treatment of SLE.