CRISPR/Cas9系统在传染病诊疗中的应用进展

Advances in application of CRISPR/Cas9 system in diagnosis and treatment of infectious diseases

CRISPR/Cas系统是一种源自细菌和古细菌的适应性免疫系统,经人工改造后发展成为一种强大的基因编辑工具,使基础科学研究发生了革命性的变化。其中,CRISPR/Cas9系统是研究最为深入、发展最快的一种。随着CRISPR/Cas9系统的不断发展,越来越多关于CRISPR/Cas9系统的疗法进入临床试验。本文简要介绍CRISPR/Cas9系统的结构和作用机制,并对其在传染病诊疗中的应用进行综述。

Clustered regularly interspaced short palindromic repeat/associated proteins(CRISPR/Cas)system,an adaptive immune system derived from bacteria and archaea,has engineered and developed into a powerful genome editing tool,which has revolutionized the basic scientific research.CRISPR/Cas9 system is the most deeply researched and fastest growing system.With the development of CRISPR/Cas9 system,increasing number of therapies about CRISPR/Cas9 system have entered clinical trials.This paper briefly introduces the structure and mechanism of CRISPR/Cas9 system,and reviews its application in the diagnosis and treatment of infectious diseases.