环状RNA作为内源性竞争RNA参与调控骨性关节炎的发生

Circular RNA as a competing endogenous RNA is involved in the regulation of osteoarthritis

背景:骨性关节炎是导致老年人关节慢性疼痛和活动受限的主要原因。环状RNA作为内源性竞争RNA调节网络新兴的重要成员,在骨性关节炎的发生发展中起着重要作用。目的:对circRNA及其生物学功能和内源性竞争RNA进行概述,并着重综述环状RNA作为内源性竞争RNA在骨性关节炎的作用的研究进展。方法:检索中国知网、万方数据库、维普中文期刊数据库、PubMed数据库,以“骨关节炎,环状RNA,内源性竞争RNA”为中文检索词,以“osteoarthritis,circular RNA,competing endogenous RNA”为英文检索词进行检索,排除陈旧以及重复的观点,将检索到的文献进行整理,选取64篇文献进行综述。结果与结论:①环状RNA影响骨关节炎发生的作用机制主要是作为内源性竞争RNA结合微小RNA,从而调控其靶基因的表达水平,从而能够调控其所属细胞的相关增殖、凋亡和分化;②环状RNA作为内源性竞争RNA参与调控软骨细胞的增殖、凋亡与自噬;③环状RNA作为内源性竞争RNA参与调控软骨细胞细胞外基质的形成与降解;④环状RNA作为内源性竞争RNA参与调控软骨细胞炎症因子的产生;⑤环状RNA作为内源性竞争RNA参与调控滑膜细胞的凋亡及自身免疫反应等;⑥由于环状RNA具有高度稳定性和保守性的特点,因此对环状RNA介导的内源性竞争RNA调节网络的研究也将为骨性关节炎的基础研究开辟新的途径,能更加全面了解骨性关节炎的发病机制,环状RNA也有望成为骨性关节炎优质的早期诊断标志物和治疗靶点;⑦目前内源性竞争RNA调节网络仍处于验证阶段,随着生物信息学的高速发展,内源性竞争RNA调节网络还需进一步改进和补充。

BACKGROUND:Osteoarthritis is one of the most common joint diseases and the leading cause of chronic joint pain and limited mobility in older adults.As an emerging important member of the competing endogenous RNA regulatory network,circular RNA plays an important role in the occurrence and development of osteoarthritis.OBJECTIVE:To overview circular RNAs,their biological functions,and competing endogenous RNAs and to emphatically review the research progress in the role of circular RNAs as competing endogenous RNAs in osteoarthritis.METHODS:CNKI,WanFang,VIP Chinese journal database,and PubMed databases were searched for relevant articles using“osteoarthritis,circular RNA,competing endogenous RNA”as Chinese and English search terms.We excluded outdated and repeated views,sorted out the retrieved literature,and selected 64 articles for review.RESULTS AND CONCLUSION:The mechanism of circular RNAs by which affect the occurrence of osteoarthritis is mainly to bind microRNAs as competing endogenous RNAs,thereby regulating the expression level of their target genes and regulating the related proliferation,apoptosis and differentiation of the cells to which they belong.Circular RNA as a competing endogenous RNA participates in regulating the proliferation,apoptosis,and autophagy of chondrocytes.Circular RNA as a competing endogenous RNA participates in regulating the formation and degradation of the extracellular matrix of chondrocytes.Circular RNA as a competing endogenous RNA is involved in regulating the production of inflammatory factors in chondrocytes.Circular RNA as a competing endogenous RNA is involved in regulating synovial cell apoptosis and autoimmune responses.Since circular RNAs are highly stable and conserved,the research on the competing endogenous RNA regulatory network mediated by circular RNAs will also open up new avenues for basic research on osteoarthritis,which help understand the pathogenesis of osteoarthritis more comprehensively.Circular RNA is also expected to be a high-quality early diagnostic marker and therapeutic target for osteoarthritis.To date,the competing endogenous RNA regulatory network is still in the verification stage.With the rapid development of bioinformatics,the competing endogenous RNA regulatory network needs to be further improved and supplemented.