七叶皂苷钠片联合盐酸氟桂利嗪治疗偏头痛的效果研究

Therapeutic effect of sodium aescinate tablet combined with flunarizine hydrochloride in the treatment of migraine

目的探究七叶皂苷钠片联合盐酸氟桂利嗪胶囊治疗偏头痛的疗效以及不良反应发生情况。方法选取2020年4月—2021年4月蚌埠医学院第一附属医院神经内科诊治的偏头痛患者100例,按照随机数字表法分为对照组(50例)与观察组(50例)。对照组患者采取盐酸氟桂利嗪胶囊治疗,观察组采取七叶皂苷钠片联合盐酸氟桂利嗪胶囊治疗,观察2组患者的治疗有效率、疼痛评分、脑血流速度、超敏C反应蛋白(hs-CRP)水平及不良反应发生情况。结果治疗前2组患者的基本资料差异无统计学意义,具有可比性;治疗后观察组疼痛评分为(3.7±1.3)分,对照组疼痛评分为(4.3±1.5)分,观察组疼痛评分低于对照组,差异有统计学意义(P<0.05);治疗后观察组总有效率为92.0%,对照组总有效率为70.0%,差异有统计学意义(P<0.05);治疗后2组患者大脑前动脉、大脑中动脉、大脑后动脉及椎动脉脑血流速度均减低,观察组低于对照组,差异有统计学意义(均P<0.05);治疗后观察组患者hs-CRP为(4.2±0.4)mg/L,对照组患者hs-CRP为(4.5±0.6)mg/L,观察组hs-CRP水平低于对照组,差异有统计学意义(P<0.05)。结论七叶皂苷钠片联合盐酸氟桂利嗪胶囊治疗偏头痛能显著增加疗效,可明显缓解患者的疼痛症状,减低疼痛评分、脑血流速度及超敏C反应蛋白水平,且不增加不良反应。

Objective To explore the efficacy of sodium aescinate tablets combined with flunarizine hydrochloride capsules in the treatment of migraine and the occurrence of adverse reactions.Methods A total of 100 migraine patients diagnosed and treated in the First Affiliated Hospital of Bengbu Medical College from April 2020 to April 2021 were selected and divided into the control group(50 cases)and observation group(50 cases)according to the random number table method.The control group was treated with flunarizine hydrochloride capsule,whereas the observation group was treated with sodium aescinate tablets combined with flunarizine hydrochloride capsule.The treatment efficiency rate,pain score,cerebral blood flow velocity,high-sensitivity C-reactive protein(hs-CRP)level and occurrence of adverse reactions in the two groups were observed.Results There was no statistically significant difference in the basic data between the two groups before treatment,which was comparable.After treatment,the pain score of the observation group was(3.7±1.3)points,and that of the control group was(4.3±1.5)points.The pain score of the observation group was significantly reduced,and the difference was statistically significant(P<0.05).After treatment,the total effective rate was 92.0% in the observation group and 70.0% in the control group,and the difference was statistically significant(P<0.05).After treatment,the cerebral blood flow velocity of the anterior cerebral artery,middle cerebral artery,posterior cerebral artery and vertebral artery in the two groups decreased,and the decrease was more significant in the observation group,with statistical significance(P<0.05).After treatment,the hs-CRP level in the observation group was(4.2±0.4)mg/L,and that in the control group was(4.5±0.6)mg/L.The decrease of the hs-CRP level in the observation group was more significant,and the difference was statistically significant(P<0.05).Conclusion Sodium aescinate tablet combined with flunarizine hydrochloride capsule in the treatment of migraine can significantly increase the efficacy,significantly relieve the pain symptoms of patients,reduce the pain score,cerebral blood flow velocity and hs-CRP level,and does not increase adverse reactions.