茵栀黄口服液联合双歧杆菌四联活菌治疗新生儿黄疸的效果分析

Analysis of the curative effect of Yinzhihuang oral liquid combined with bifidobacterium tetragenous viable bacteria in the treatment of neonatal jaundice

目的评估联合应用双歧杆菌四联活菌片、茵栀黄口服液治疗新生儿黄疸的疗效及安全性。方法选取2019年5月—2020年12月安徽中医药大学第一附属医院住院新生儿黄疸患儿50例,采用随机数字表法分为观察组和对照组,每组各25例。2组均给予蓝光光疗、肝酶诱导剂苯巴比妥口服的常规治疗,对照组给予常规治疗+双歧杆菌四联活菌0.5 g温水冲服,3次/d,观察组给予常规治疗+双歧杆菌四联活菌0.5 g,温水冲服,3次/d,茵栀黄口服液5 mL,口服,3次/d。对比2组治疗前后血清总胆红素、直接胆红素、间接胆红素水平、不良反应发生率、光疗总时间、光疗总费用、住院时间。结果治疗前2组总胆红素、直接胆红素、间接胆红素比较差异无统计学意义(均P>0.05)。治疗后2组直接胆红素比较差异无统计学意义(P>0.05)。治疗后观察组血清总胆红素为(118.78±23.43)μmol/L,间接胆红素为(106.89±22.39)μmol/L,显著低于对照组[(135.41±28.66)μmol/L、(123.31±27.77)μmol/L,均P<0.05]。观察组不良反应发生率为4.00%(1/25),对照组为24.00%(6/25),2组比较差异无统计学意义(P>0.05)。观察组光疗总时间、光疗总费用、住院时间均显著低于对照组(均P<0.05)。结论新生儿黄疸在常规治疗基础上,联合应用双歧杆菌四联活菌、茵栀黄口服液,临床疗效显著,可减少住院时间,降低光疗费用,是安全、有效的治疗方法。

Objective To evaluate the efficacy and safety of the combined application of bifidobacterium tetragenous viable bacteria and Yinzhihuang oral liquid in the treatment of neonatal jaundice.Methods Total 50 patients with neonatal jaundice in the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from May 2019 to December 2020 were selected and randomly divided into control and observation groups,with 25 cases in each group.Both groups were treated with blue light phototherapy and oral administration of liver enzyme inducer phenobarbital.The control group was treated with conventional treatment+bifidobacterium tetragenous viable bacteria 0.5 g with warm water three times/day.On the basis of the control group,the observation group was treated with Yinzhihuang oral liquid 5 mL/time,oral,3 times/d.The differences of various indexes between the two groups before and after treatment were compared.Results There was no significant difference in total bilirubin,direct bilirubin and indirect bilirubin between the two groups before treatment(all P>0.05).After treatment,there was no significant difference in indirect bilirubin between the two groups(P>0.05),meanwhile,the total bilirubin and indirect bilirubin of the observation group[(118.78±23.43)and(106.89±22.39)μmol/L]were significantly lower than those of the control group[(135.41±28.66)and(123.31±27.77)μmol/L,all P<0.05].The incidence of adverse reactions in the observation group was 4.00%(1/25),and that in the control group was 24.00%(6/25).There was no statistically significant difference between the two groups(P>0.05).The total time of phototherapy,the total cost of phototherapy and the length of stay in the observation group were significantly lower than those in the control group,and the difference was statistically significant(all P<0.05).Conclusion On the basis of conventional treatment for neonatal jaundice,the combined application of bifidobacterium tetragenous viable bacteria and Yinzhihuang oral liquid has a significant clinical effect,reduces hospitalisation time and the cost of phototherapy,and is a safe and effective treatment method.