摘要
纳米医学的兴起为肿瘤疫苗的研发带来新的契机。纳米佐剂系统在抗原的靶向递送与可控缓释中发挥重要作用;同时也为免疫活化提供共刺激信号,发挥协同活化作用。综述基于合成与生物衍生材料的纳米佐剂的应用,重点讨论纳米佐剂免疫调节、药物递送以及联合治疗的现状,并对纳米佐剂的应用前景进行展望。
The development of nanomedicine has brought new opportunities for tumor vaccine research. The nanoadjuvant system plays an important role in the targeted delivering and controlled releasing of antigens, and exerts synergistic immune activation by transmitting costimulatory signals. This article reviews the application of nanoadjuvants based on synthetic and natural materials, and describes the status of nanoadjuvants in immunomodulation, drug delivery and combination therapy, with a prospect of the future application and further study of nanoadjuvants.
作者
张莉莉
向韡
刘超
刘刚
ZHANG Lili;XIANG Wei;LIU Chao;LIU Gang(Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration,Guangxi Collaborative Innovation Center for Biomedicine,Guangxi Medical University,Nanning 530021,China;Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361102,China)
出处
《药学进展》
CAS
2022年第4期296-302,共7页
Progress in Pharmaceutical Sciences
基金
国家重点研发计划项目(2017YFA0205201)
国家自然科学基金(81925019,81422023,U1705281)
教育部新世纪优秀人才支持计划项目(ncet-13-0502)
中央高校基本科研业务费(20720190088,20720200019)。
关键词
肿瘤疫苗
纳米佐剂
联合治疗
tumor vaccine
nanoadjuvant
combination therapy
