微纳米尺度生物体温度测量方法及展望

The Development and Future of Temperature Measurement for Biosome and Cells in Micro-nano Meter Scale

温度是描述凝聚态物质系统热力学状态和演变的基本参数。微纳米级的温度传感在生物体(细胞)、芯片、低维人工材料等领域中有着重要的应用前景,可作为定量化观测生物体活动能力、化学反应、生命演变的技术途径。鉴于该类型温度传感器的种类繁多、计量性能差异明显,主要从测温技术特点和计量性能两个方面,对应用于微纳米尺度生物体测温的微纳热电偶、热电阻、红外热像仪、磁性纳米粒子和荧光发光等类型的温度测量方法进行了综述和比较分析,并展望了微纳米尺度生物体温度测量领域的发展前景。

Temperature is the fundamental parameter to describe the thermodynamic state and evolution of condensed matter.Temperature sensing in micro-nano meter scale has important applications in the fields of organisms and cells,chips,low-dimensional artificial materials and so on.It can provide another point of view to understand the activity of biosome,the chemical reaction and evolution with quantitative technique.Considering the obvious metrological differences between various temperature sensors,the comparison of metrological characteristics of different thermometers including micro-nano thermocouples,thermistors,infrared thermal imagers,magnetic nanoparticles and fluorescent materials were focused on.The future of temperature sensors for biosome and cells in micro-nano meter scale was also analyzed.