白癜风样小鼠皮肤脱色模型研究进展与思考

Research progress and thinking in mouse models of vitiligo-like depigmentation

白癜风的病因及发病机制均未明确,动物模型是白癜风研究的重要工具。除传统的白癜风小鼠模型外,许多新模型逐渐建立,如表达表皮黑素细胞、黑素细胞反应性T细胞的小鼠模型、K14-SCF/h3TA2/HLA-A2三转基因(Vitesse鼠)小鼠模型、自身免疫诱导的小鼠模型、化学试剂诱导的小鼠模型等,这些模型与人白癜风高度相似,在可重复性和稳定性等方面都有不同程度提高,已成为研究白癜风发病机制、探索治疗靶点和评判疗效的良好模型。本文综述目前白癜风样小鼠脱色模型的研究进展,并分析存在的问题。

The etiology and pathogenesis of vitiligo have not yet been clear,and animal models are important tools for vitiligo research.In addition to traditional mouse models of vitiligo,many new models have been gradually established with the deepening of research,such as mouse models expressing epidermal melanocytes and melanocyte-reactive T cells,K14-SCF/h3TA2/HLA-A2 triple-transgenic mouse(Vitesse mice)models,autoimmune-induced mouse models,chemical reagent-induced mouse models,etc.Manifestations of these models are highly similar to human vitiligo,their reproducibility and stability have been improved to different extents,and they have already become good models for exploring the pathogenesis of and therapeutic targets for vitiligo,as well as for evaluating therapeutic efficacy.This review summarizes current research progress and existing problems in mouse models of vitiligo-like depigmentation.