细胞力学在皮肤科的研究进展

Cell mechanics in dermatology

细胞力学是一门新兴的交叉学科,以研究细胞的力学特性与细胞生命活动以及组织、器官、机体生理过程的关系为主。通过对力学信号的感受和响应机制,细胞参与皮肤、骨、眼等多器官组织的生理活动以及疾病的发生发展,包括皮肤组织再生、重建、适应性变化和多种皮肤病的发病,因此成为近年皮肤病研究的热点。本文综述近年来细胞力学的基础研究和其在瘢痕、压疮、白癜风、皮肤肿瘤、毛发疾病等方面的研究和应用进展,为皮肤病治疗提供可能的方法和策略。

Cell mechanics is a new interdiscipline,which focuses on the relationship between cell mechanical properties and cell behaviors,as well as physiological processes in tissues,organs and the body.Through the perception of and response to mechanical signals,cells participate in physiological activities of skin,bones,eyes and other organs,and the occurrence and development of diseases,including the regeneration,reconstruction and adaptive changes of skin tissues and the pathogenesis of various skin diseases.Cell mechanics has become a hot spot in the research of skin diseases in recent years.This review summarizes recent progress in cell mechanics-associated basic research,as well as in its research and application in scars,bedsores,vitiligo,skin tumors,hair diseases,etc.,aiming to provide possible methods and strategies for the treatment of skin diseases.