摘要
人呼吸道合胞病毒(HRSV,Human respiratory syncytial virus)是全球婴幼儿罹患严重下呼吸道疾病感染的主要原因,也是老年人和免疫缺陷者发病、住院和死亡的重要因素,严重威胁婴幼儿、老年人和免疫缺陷者的健康。深入了解HRSV的的生物学特性、致病机理及其对相关免疫应答的影响,对研发安全有效的抗HRSV疫苗、建立积极的预防措施,以减少疾病发生率和重症病例死亡率,具有十分重要的促进作用。
The human respiratory syncytial virus(HRSV)is the main cause of severe infection of the lower respiratory tract in infants and young children worldwide. HRSV infection is also an important factor in the incidence,hospitalization,and death of infants,older individuals,and people with an immune deficiency. Indepth understanding of the biological characteristics and pathogenesis of the HRSV and its impact on the immune response has an important role in:(i)promoting the development of a safe and efficacious anti-HRSV vaccine;(ii) taking preventive measures to reduce the risk of disease and mortality in people with severe infection.
作者
郑海涛
丁樱
任献青
袁斌
马淑霞
李向峰
孙晓旭
邱建利
韩姗姗
闫永彬
ZHENG Haitao;DING Ying;REN Xianqing;YUAN Bin;MA Shuxia;LI Xiangfeng;SUN Xiaoxu;QIU Jianli;HAN Shanshan;YAN Yongbin(The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Henan Children’s Hospital of Integrative Medicine,Zhengzhou 450003,China;Nanjing Hospital,Nanjing University of Traditional Chinese Medicine,Nanjing 210029,China)
出处
《病毒学报》
CAS
CSCD
北大核心
2022年第3期724-730,共7页
Chinese Journal of Virology
基金
国家自然科学基金面上项目(项目号:81574025、81873340、81973903):题目:基于调节Th细胞亚群平衡的清肺口服液抗呼吸道合胞病毒感染的蛋白质组学研究、I型干扰素通路介导的清肺口服液类黄酮组分抗RSV的机制研究、基于哮喘中西医病机交通性之搜风愈喘方及其拆方调控哮喘大鼠气道重塑机制的实验研究。
关键词
人呼吸道合胞病毒
感染
免疫应答
炎症反应
Human respiratory syncytial virus(HRSV)
Infection
Immune response
Inflammatory response
