暂停肠道喂养对新生儿输血相关性坏死性小肠结肠炎的保护作用分析

Protective effect of intestinal feeding suspension on neonatal transfusion related necrotizing enterocolitis

目的:探讨暂停肠道喂养对新生儿输血相关性坏死性小肠结肠炎(TRNEC)的保护作用。方法:选取2017年3月—2021年3月临沂市妇幼保健院收治的100例输血治疗患儿,将其随机分为对照组和观察组各50例。对照组按正常喂养时间进行肠道喂养,观察组输血后6 h再开始肠道喂养。观察两组患儿炎症因子水平、腹围、TRNEC相关症状发生率和TRNEC发生率。结果:输血后6 h、12 h时,观察组C反应蛋白(CRP)、降钙素原(PCT)、白细胞(WBC)水平和腹围均低于对照组,且腹胀、呕吐、血便发生率和TRNEC发生率均低于对照组,差异均有统计学意义(P<0.05)。结论:暂停肠道喂养可保护新生儿尚未发育成熟的胃肠道,降低CRP、PCT、WBC等炎性因子水平,起到肠道保护作用,从而预防TRNEC发生。

Objective To investigate the protective effect of intestinal feeding suspension on neonatal transfusion related necrotizing enterocolitis(trnec).Methods 100 children treated with blood transfusion from March 2017 to March 2021 were randomly divided into control group and observation group.The control group was fed with intestinal feeding according to the normal feeding time,and the observation group began intestinal feeding 6 hours after blood transfusion.The levels of inflammatory factors,abdominal circumference,the incidence of trnec related symptoms and the incidence of trnec were observed.Results The levels of CRP,PCT,WBC and abdominal circumference in the observation group at 6 h and 12 h after blood transfusion were lower than those in the control group,and the incidence of abdominal distension,vomiting,bloody stool and trnec were lower than those in the control group(P<0.05).Conclusion Suspending intestinal feeding can protect the immature gastrointestinal tract of newborns,and play an intestinal protective role by controlling inflammatory factors such as CRP,PCT and WBC,so as to prevent trnec.