摘要
类风湿关节炎(rheumatoid arthritis, RA)是一种慢性、系统性、进行性、自身免疫性疾病,同时还会并发内脏损伤疾病,缩短患者寿命,导致死亡率升高.淋巴管系统功能在RA疾病过程中占有重要地位,促进其功能可以缓解RA疾病进展.淋巴管系统作为具有回流功能的全身性的大型网络结构,在内脏损伤疾病过程中也发挥重要作用.在中医理论中, RA及其内脏损伤并发症的发生属于“五体痹”向“五脏痹”的传变过程.本文综述了淋巴管系统在RA以及内脏损伤疾病过程中的作用,结合本团队前期中医药靶向调节淋巴管系统治疗RA的研究成果,探讨淋巴管系统在RA及其内脏并发症病理进程中的作用和机制,以及中医药疗法机制,为临床RA内脏并发症的治疗提供新思路和潜在治疗方案.进一步解释从“五体痹”到“五脏痹”传变的内在规律,丰富中医“痹证”理论的科学内涵.
Rheumatoid arthritis(RA) is an autoimmune disease characterized by persistent synovitis, systemic inflammation, and autoantibodies. At the same time, it will be complicated by visceral injury, shortening the life of patients and increasing the mortality.The lymphatic system plays an important role in the process of RA disease. Promoting its function can alleviate the progress of RA disease. As a large systemic network structure with reflux function, lymphatic system also plays an important role in the process of visceral injury.In the theory of traditional Chinese medicine(TCM), the occurrence of RA and its visceral injury complications belongs to the transmission process of “wu ti bi” and “Wu zang bi”. This paper reviews the role of lymphatic system in the process of RA and visceral injury. Based on previous research results of our team on the targeted regulation of lymphatic system by TCM in the treatment of RA, this paper discusses the role and mechanism of lymphatic system in the pathological process of RA and its visceral complications, as well as the therapeutic mechanism of TCM, so as to provide new ideas and potential therapeutic schemes for the treatment of visceral complications of RA, which would further explain the internal law of transmission from “wu ti bi” to “wu zang bi”, and enrich the scientific connotation of TCM “arthralgia syndrome” theory.
作者
李雪菲
袁璐莹
杨灿
王怿
阮铭
王佑华
施杞
王拥军
梁倩倩
LI XueFei;YUAN LuYing;YANG Can;WANG Yi;RUAN Ming;WANG YouHua;SHI Qi;WANG YongJun;LIANG QianQian(Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Spine Institute,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Key Laboratory of Bone Theory and Governance,Ministry of Education,Shanghai 200032,China)
出处
《中国科学:生命科学》
CSCD
北大核心
2022年第6期849-858,共10页
Scientia Sinica(Vitae)
基金
国家重点研发计划(批准号:2018YFC1704300)
国家自然科学基金优秀青年科学基金(批准号:81822050)、国家自然科学基金重点国际合作与交流项目(批准号:81920108032)
上海市医学领军人才(批准号:2019LJ02)
上海市曙光计划(批准号:19SG39)
教育部创新团队发展计划(批准号:IRT1270)
科技部重点领域创新团队计划(批准号:2015RA4002)
上海市“重中之重”临床医学中心(批准号:2017ZZ01010)资助。
关键词
淋巴管系统
RA
RA并发症
五体痹
五脏痹
lymphatic vessel system
RA
complications of rheumatoid arthritis
wu ti bi
wu zang bi