载药微球肝动脉化疗栓塞术治疗大肝癌的临床效果及安全性

Clinical effect and safety of drug-loaded microspheres hepatic artery chemoembolization in the treatment of large hepatocellular carcinoma

目的探究载药微球肝动脉化疗栓塞术治疗大肝癌的临床效果及安全性。方法选择2019年1月至2020年12月我院收治的58例大肝癌患者作为研究对象,采用随机数字表法将其分为对照组、研究组,各29例。对照组开展传统肝动脉化疗栓塞术治疗,研究组开展载药微球肝动脉化疗栓塞术治疗。比较两组的临床疗效、生活质量、不良反应发生情况、肝功能指标[谷丙转氨酶(ALT)、总胆红素(TBIL)、谷草转氨酶(AST)、碱性磷酸酶(ALP)]水平。结果研究组的治疗总有效率为93.10%,显著高于对照组的72.41%,差异具有统计学意义(P<0.05)。治疗前,两组的功能领域、总体健康状况领域、症状领域评分比较,差异无统计学意义(P>0.05);治疗1个月后,两组的功能领域、总体健康状况领域评分均较治疗前升高,症状领域评分均较治疗前降低,且研究组优于对照组,差异具有统计学意义(P<0.05)。对照组的不良反应总发生率为13.79%,研究组的不良反应总发生率为10.34%,两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。治疗前,两组的ALT、TBIL、AST、ALP水平比较,差异无统计学意义(P>0.05);治疗1个月后,两组的ALT、TBIL、AST、ALP水平均降低,且研究组低于对照组,差异具有统计学意义(P<0.05)。结论载药微球肝动脉化疗栓塞术治疗大肝癌的临床效果显著,可提高患者的生活质量,改善肝功能指标,且不增加不良反应发生率,安全性高,值得临床推广和应用。

Objective To explore the clinical effect and safety of drug-loaded microspheres hepatic artery chemoembolization in the treatment of large hepatocellular carcinoma.Methods A total of 58 patients with large hepatocellular carcinoma admitted in our hospital from January 2019 to December 2020 were selected as the study objects.The patients were divided into control group and study group by random number table method,with 29 cases in each group.The control group was treated with traditional hepatic artery chemoembolization,and the study group was treated with drug-loaded microspheres hepatic artery chemoembolization.The clinical efficacy,quality of life,adverse reactions and the levels of liver function indexes[alanine aminotransferase(ALT),total bilirubin(TBIL),aspartate aminotransferase(AST),alkaline phosphatase(ALP)]were compared between the two groups.Results The total effective rate of treatment of the study group was 93.10%,which was significantly higher than 72.41%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the scores of functional area,general health status area and symptom area between the two groups(P>0.05);after one month of treatment,the scores of functional area and overall health status area in the two groups were higher than those before treatment,the score of symptom area was lower than that before treatment,and those in the study group were better than the control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the control group was 13.79%,and the total incidence of adverse reactions in the study group was 10.34%,there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Before treatment,there were no significant differences in the levels of ALT,TBIL,AST and ALP between the two groups(P>0.05);after one month of treatment,the levels of ALT,TBIL,AST and ALP in the two groups decreased,and those in the study group were lower than the control group,the differences were statistically significant(P<0.05).Conclusion The drug-loaded microspheres hepatic artery chemoembolization in the treatment of large hepatocellular carcinoma has remarkable clinical effect,it can improve the quality of life of patients,ameliorate liver function indexes,and do not increase the incidence of adverse reactions,which is safe and worthy of clinical promotion and application.