奥卡西平联合丙戊酸钠治疗癫痫部分性发作的效果研究

Effect research of oxcarbazepine combined with sodium valproate in the treatment of partial seizures

目的:探讨奥卡西平联合丙戊酸钠治疗癫痫部分性发作的效果。方法:随机抽取2018年9月—2020年9月江西省宜春市人民医院接诊所有癫痫部分性发作患者中病历资料完整的60例患者,按照随机数字表对照法分为两组,每组30例。对照组接受奥卡西平治疗,初始150 mg/次,口服,2次/d,1~2周后逐步增加至450 mg/次,2次/d;观察组在此基础上加用丙戊酸钠,0.2 g/次,口服,3次/d。两组均连续治疗2个月。比较两组治疗效果、用药期间不良反应以及认知功能量表(MMSE)评分、生活质量量表(QOLIE-31)评分的变化情况。结果:观察组治疗总有效率为90.00%(27/30),高于对照组的66.67%(20/30,P<0.05)。干预后,观察组MMSE评分高于对照组(P<0.05),社会功能、发作的担心、药物影响、精力疲乏、认知功能、情绪、综合生活质量评分也均高于对照组(P<0.05)。观察组和对照组不良反应总发生率对比,差异无统计学意义(P>0.05)。结论:奥卡西平联合丙戊酸钠治疗癫痫部分性发作较单独用药效果明显提升,能够有效改善患者的认知功能和生活质量,且安全性良好,值得临床推荐。

Objective:To investigate the effect of oxcarbazepine combined with sodium valproate in the treatment of partial seizures.Methods:Sixty patients with partial seizures who were treated in Yichun People’s Hospital of Jiangxi Province from September 2018 to September 2020 and had complete medical records were randomly selected and divided into two groups with 30 cases in each group according to the random number table.The control group was treated with oxcarbazepine,initially 150 mg/time,orally,twice a day,and gradually increased to 450 mg/time,twice a day in 1~2 weeks;on this basis,the observation group was added with sodium valproate,0.2 g/time,orally,3 times/d.Both groups were treated continuously for 2 months.The treatment effect,adverse reactions during medication,the scores of cognitive function scale(MMSE)and quality of life scale(QOLIE-31)were compared between the two groups.Results:The total effective rate of the observation group was 90.00%(27/30),which was higher than that of the control group 66.67%(20/30,P<0.05).After the intervention,the MMSE score of the observation group was higher than that of the control group(P<0.05),and the scores of social function,fear of attack,drug influence,energy fatigue,cognitive function,emotion and comprehensive quality of life of the observation group were also higher than those of the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion:Oxcarbazepine combined with sodium valproate in the treatment of partial seizures is significantly better than that alone,which can effectively improve the cognitive function and quality of life of the patients,and has good safety,which is worthy of clinical recommendation.