纤维蛋白原、白蛋白表达水平与老年不稳定心绞痛患者预后的相关性

Study on the Relationship between the Expressions of Fibrinogen and Albumin and Unstable Angina Pectoris in the Elderly and its Prognosis

【目的】探讨纤维蛋白原(FIB)和白蛋白(ALB)表达水平与老年不稳定心绞痛患者预后的相关性。【方法】选择2018年1月至2019年2月西安市第一医院收治的120例老年不稳定心绞痛患者(观察组),选择同期于同院健康体检的120例健康志愿者(对照组)。分别检测两组研究对象血清FIB、ALB水平,通过研究受试者工作特征(ROC)曲线评估FIB、ALB水平对不稳定心绞痛的诊断价值,采用多因素Cox模型分析影响不稳定心绞痛患者预后不良的相关因素。【结果】观察组血清FIB水平高于对照组,ALB水平低于对照组,差异有统计学意义(P<0.05)。ROC曲线分析显示,FIB和ALB诊断不稳定心绞痛的AUC分别为0.886、0.781,截断值分别为2.743 g/L、40.98 g/L,联合检测不稳定心绞痛的曲线下面积(AUC)为0.927,灵敏度和特异性分别为88.3%、88.3%。高FIB组患者预后不良发生率高于低FIB组(P<0.05),低ALB组患者预后不良发生率高于高ALB组(P<0.05)。多因素Cox模型分析显示,FIB高水平、ALB低水平是不稳定心绞痛患者预后的独立危险因素(均P<0.05)。【结论】不稳定心绞痛患者血清FIB水平明显升高,血清ALB水平明显降低,FIB、ALB对不稳定心绞痛具有一定诊断价值,且高FIB和低ALB表达水平患者预后不良发生风险较高。

【Objective】To investigate the correlation between the expression levels of fibrinogen(FIB)and albumin(ALB)and the prognosis of elderly patients with unstable angina pectoris.【Methods】A total of 120 elderly patients with unstable angina pectoris(observation group)treated in Xi'an first hospital from January 2018 to February 2019 were selected,and 120 healthy volunteers(control group)who underwent physical examination in our hospital at the same time were selected.The serum FIB and ALB levels of the two groups were detected respectively.The diagnostic value of FIB and ALB levels in patients with unstable angina pectoris was evaluated by the working characteristic curve(ROC).The related factors affecting the poor prognosis of patients with unstable angina pectoris were analyzed by multivariate Cox model.【Results】The level of serum FIB in the observation group was higher than that in the control group,and the level of Alb was lower than that in the control group(P<0.05).ROC curve analysis showed that the AUC of FIB and ALB in the diagnosis of unstable angina pectoris were 0.886 and 0.781 respectively,and the cut-off values were 2.743 g/L and 40.98 g/L respectively.The AUC of combined detection of unstable angina pectoris was 0.927,and the sensitivity and specificity were 88.3%and 88.3%respectively.The incidence of poor prognosis in the high FIB group was higher than that in the low FIB group(P<0.05),and the incidence of poor prognosis in the low ALB group was higher than that in the high ALB group(P<0.05).Multivariate Cox model analysis showed that high FIB level and low ALB level were independent risk factors for the prognosis of patients with unstable angina pectoris(all P<0.05).【Conclusion】The level of serum FIB in patients with unstable angina pectoris is significantly increased and the level of serum ALB is significantly reduced.FIB and ALB have certain diagnostic value for unstable angina pectoris,and patients with high FIB and low ALB expression have a high risk of poor prognosis.