急性肾盂肾炎患者血浆中presepsin、IL-6的表达水平及其意义

Expression and Significance of Plasma Presepsin and IL-6 in Patients with Acute Pyelonephritis

【目的】探讨可溶性白细胞分化抗原14亚型(presepsin)、白细胞介素(IL-6)在急性肾盂肾炎患者血浆中的表达水平及其意义。【方法】本院收治的急性肾盂肾炎患者113例为观察组,根据临床症状的差异分为早期组91例,晚期组22例;另选取同期健康体检人员115例作为对照组,检测各组presepsin、IL-6水平及相关指标的表达水平,分析presepsin、IL-6水平与肾小球滤过率(GFR)的相关性,受试者工作特征(ROC)曲线分析血浆presepsin、IL-6对早期急性肾盂肾炎的预测价值。【结果】观察组患者白细胞计数(WBC)、C反应蛋白(CRP)、胱抑素C(CysC)、降钙素原(PCT)、血肌酐(SCr)、presepsin、IL-6表达水平均明显高于对照组(P<0.05),GFR低于对照组(P<0.05)。与早期组比较,晚期组患者血浆presepsin、IL-6表达水平升高,且差异有统计学意义(P<0.05);急性肾盂肾炎患者血浆presepsin、IL-6表达水平与WBC、CRP、SCr水平呈正相关(P<0.05),与GFR呈负相关(P<0.05)。血浆presepsin、IL-6联合预测早期急性肾盂肾炎的曲线下面积为0.928,敏感度为81.82%,特异度为90.11%。【结论】急性肾盂肾炎患者血浆中presepsin、IL-6呈高表达,且与患者WBC、CRP、SCr水平有关,其可作为预测早期急性肾盂肾炎的潜在标志物。

【Objective】To investigate the expressions and significance of presepsin and interleukin(IL-6)in plasma of patients with acute pyelonephritis.【Methods】A total of 113 patients with acute pyelonephritis admitted to our hospital from October 2018 to May 2020 were selected as the observation group.According to the difference in clinical symptoms,they were divided into in the early group(91 cases)and in the late group(22 cases).Volunteers of 115 cases with health examination personnel were selected as the control group.The expression of presepsin and IL-6 was detected,the correlation between the levels of presepsin and IL-6 and glomerular filtration rate(GFR)was analyzed,and the predictive value of plasma presepsin and IL-6 in patients with early acute pyelonephritis was analyzed by ROC curve.【Results】Compared with those in the control group,the levels of WBC,C-reactive protein(CRP),Cystatin C(CysC),procalcitonin(PCT),serum creatinine(SCr),presepsin and IL-6 in the observation group were significantly higher(P<0.05),while the GFR was lower(P<0.05).compared to the early group,the expression levels of plasma presepsin and IL-6 in the late group were higher(P<0.05).The levels of plasma presepsin and IL-6 in patients with acute pyelonephritis were positively correlated with WBC,CRP and SCr(P<0.05),and negatively correlated with GFR(P<0.05).The area under the curve of plasma presepsin and IL-6 in patients with early acute pyelonephritis was 0.928,the sensitivity was 81.82%and the specificity was 90.11%.【Conclusion】The high expressions of presepsin and IL-6 in plasma of patients with acute pyelonephritis are related to the levels of WBC,CRP,and SCr,which may be used as potential markers for early acute pyelonephritis.