AQP-4、VEGF表达与脑膜瘤术后脑水肿加重的相关性分析

Correlation between expressions of AQP-4 and VEGF and postoperative cerebral edema exacerbation in patients with meningioma

目的 探讨水通道蛋白4(AQP-4)、血管内皮生长因子(VEGF)表达与脑膜瘤术后脑水肿加重的相关性。方法 收集2019年1月至2020年1月手术切除并经术后病理确诊的脑膜瘤组织105例,免疫组化染色检测AQP-4和VEGF的表达。术后2-15 d复查头部MRI判断脑水肿。结果 105例中,术后脑水肿加重30例(28.57%),未加重75例。术后脑水肿加重组AQP-4阳性表达率(63.3%)和VEGF阳性表达率(30.0%)较未加重组明显增加(分别为30.7%和16.0%;P<0.05)。多因素logistic回归分析显示,AQP-4和VEGF阳性表达是脑膜瘤术后脑水肿加重的独立危险因素(P<0.05)。结论 AQP-4和VEGF表达上调与脑膜瘤术后脑水肿加重有关。

Objective To investigate the correlation between the expressions of aquaporin 4(AQP-4) and vascular endothelial growth factor(VEGF) and the aggravation of postoperative cerebral edema in the patients with meningioma. Methods The expressions of AQP-4 and VEGF were detected by immunohistochemical staining in meningioma tissues obtained from 105 patients who underwent microsurgery from January 2019 to January 2020. The aggravation of postoperative peritumoral edema was detected by head MRI 2-15days after operation. Results The aggravation of postoperative cerebral edema occurred in 30 patients(28.57%;edema group) of 105patients, and did not in 75 patients(non-edema group). The positive expression rates of AQP-4(63.3%) and VEGF(30.0%) in edema group were significantly higher than those(30.7% and 16.0%, respectively) in non-edema group(P<0.05). Multivariate logistic regression analysis showed that the positive expressions of AQP-4 and VEGF were independent risk factors for the aggravation of postoperative cerebral edema(P<0.05). Conclusions The up-regulation of AQP-4 and VEGF in meningioma tissue is related to the aggravation of postoperative cerebral edema in the patients with meningioma.