钯催化的烯烃异构化反应

Pd-Catalyzed Isomerization of Alkenes

烯烃异构反应可以从简单烯烃出发,通过对碳碳双键立体选择性或者位置选择性调控,实现内烯烃化合物尤其其他方法难以构建的多取代烯烃的高效合成,原子经济性高.详细介绍了钯催化烯烃异构化反应的反应机制,系统总结了钯催化的烯烃顺反异构和位置选择性异构反应,以及其在药物分子和天然产物合成中的应用.

Starting from commercially available simple olefins,alkene isomerization could realize the efficient construction of multi-substituted alkenes,which might be difficult to access with other synthetic methods,in an atom-economic manner via the stereoselective or positional-selective modulation of the carbon-carbon double bonds.The palladium catalyzed stereoselective(Z/E)and the positional selective isomerization reactions of alkenes are summarized.The mechanistic perspectives,and their synthetic applications in the synthesis of drug molecules and natural products are discussed in detail.