可回收铋配合物催化氮亲核试剂与对醌甲基化物1,6-加成:轻松获得N-杂环取代的不对称三芳基甲烷衍生物

1,6-Addition of Nitrogen Nucleophile to para-Quinone Methides Catalyzed by Recyclable Bismuth Complex:Facile Access to N-Heterocyclic Substituted Unsymmetric Triarylmethane Derivatives

开发了一种用对醌甲基化物(p-QMs)和各种芳香族N-杂环化合物1,6-氮杂-迈克尔加成合成含氮不对称三芳基甲烷衍生物的方法.这种合成方法具有反应条件温和、催化剂负载量可接受、原子经济性、易于放大的特点,并且能够以中等至优异的产率形成N-杂环取代的不对称三芳基甲烷衍生物.此外,铋催化剂可以重复使用多次而不会损失其活性.

A useful protocol for the synthesis of nitrogen-containing unsymmetric triarylmethane derivatives through 1,6-aza-Michael addition of para-quinone methides(p-QMs)and various aromatic N-heterocycles was developed.This established synthetic strategy features mild reaction conditions,acceptable catalyst loading,atom economy,easy scale-up and enables the formation of N-heterocyclic-substituted unsymmetric triarylmethane derivatives in moderate to excellent yields.Moreover,the bismuth catalyst can be reused several times without losing of its activity.