多层螺旋CT联合miR-142-5p对宫颈癌淋巴结转移的诊断分析

Diagnostic Analysis for Multi-slice Spiral CT Combined with miR-142-5p in Diagnosis of Cervical Cancer Lymph Node Metastasis

本文主要分析了多层螺旋CT联合miR-142-5p对宫颈癌淋巴结转移的诊断价值。选取疑似宫颈癌淋巴结转移的125例患者作为研究对象,将70例确诊为淋巴结转移的患者作为研究组,55例非淋巴结转移的患者作为对照组。两组均经多层螺旋CT检查,通过实时荧光定量法检测两组miR-142-5p表达量。结果发现,与对照组相比,研究组血容量(BV)、灌注值(PF)、强化峰值(PEI)参数升高,达峰时间(TTP)、miR-142-5p表达量降低,且研究组中淋巴结转移距离≥1.0 cm患者BV、PF、PEI参数最高,TTP参数、miR-142-5p表达量最低(P<0.05)。BV、TTP、PF、PEI、miR-142-5p与不同淋巴结转移距离相关,且BV、TTP、PF、PEI与miR-142-5p相关。BV、TTP、PF、PEI、miR-142-5p联合检测对宫颈癌淋巴结转移的诊断价值较高,ROC曲线下面积(AUC)为0.827(P<0.05)。多层螺旋CT联合miR-142-5p对宫颈癌淋巴结转移有较高的诊断价值,具有一定的临床推广价值。

This paper mainly analyzed the diagnostic value of multilayer spiral CT combined with miR-142-5p for cervical cancer lymph node metastasis.125 patients with suspected cervical cancer lymph node metastasis were selected as study subjects,70 patients with confirmed lymph node metastasis were assigned as the study group and 55 patients with non-lymph node metastasis as the control group.Both groups were examined by multicoil CT and the expression of miR-142-5p was determined by real-time fluorescence.The results showed that compared with the control group,the blood volume(BV),perfusion value(PF),peak enhancement(PEI)parameters of the study group increased,while the time to peak(TTP)and the expression of miR-142-5p decreased.The parameters of BV,PF,and PEI were the highest in patients with lymph node metastasis≥1.0 cm,and the expression of TTP parameters and miR-142-5p were the lowest(P<0.05).The BV,TTP,PF,PEI,miR-142-5p were related to different lymph node metastasis distances,and BV,TTP,PF,PEI were related to miR-142-5p.The combination test of BV,TTP,PF,PEI,and miR-142-5p had a high diagnostic value for cervical cancer lymph node metastasis,the area under the curve of ROC was 0.827(P<0.05).In summary,multi-slice spiral CT combined with miR-142-5p has a high diagnostic value for cervical cancer lymph node metastasis,and has a certain clinical promotion value.