细菌四类胞外感觉结构域的概述

Overview of four kinds of extracellular sensory domains in bacteria

细菌通过信号转导网络系统感知外界的环境变化,并通过调节自身基因表达,控制菌体的行为、代谢以及发育等。细菌和古细菌大多数使用双组分转导系统和化学传感系统感知环境变化。基于基因组研究发现在细菌的双组份转导系统和化学传感系统中存在多种不同的胞外结构域,这些胞外结构域能感知胞外信号,对细菌的各种生理功能具有重要作用。介绍了Cache结构域、CHASE结构域、NIT结构域以及4HB结构域这4类胞外感觉结构域的结构特性以及功能,为胞外感觉结构域的分类以及识别信号的位点提供借鉴。

Bacteria perceive environmental changes through the signal transduction network system,and control bacterial behavior,metabolism and development by regulating their own gene expression. Most bacteria and archaea use two-component transduction system and chemical sensing system to perceive environmental changes. In recent years,based on genome research,it has been found that there are many different extracellular domains in bacterial two-component transduction system and chemical sensing system.These extracellular domains can sense extracellular signals and play an important role in various physiological functions of bacteria.The structural characteristics and functions of Cache domain,CHASE domain,NIT domain and 4HB domain were introduced to provide a reference for the classification of extracellular sensory domains and the identification of signal sites.