皮下胰岛素泵与皮下注射胰岛素治疗2型糖尿病并肝脓肿的临床分析

Clinical Effect of Subcutaneous Insulin Pump and Subcutaneous Insulin Injection in the Treatment of Type 2 Diabetes Mellitus with Liver Abscess

目的探讨皮下胰岛素泵对2型糖尿病(T2DM)并肝脓肿(PLA)患者的临床疗效。方法回顾性分析绵阳市中心医院2019年7月—2020年7月收治的62例糖尿病并肝脓肿患者,根据不同降血糖方式分为观察组(n=31)和对照组(n=31)。观察组采用皮下胰岛素泵控制血糖,对照组采用门冬胰岛素30注射液控制血糖。比较两组患者治疗后空腹血糖(FPG)、餐后2 h血糖(2 hPG)、葡萄糖目标范围内时间(TIR)、葡萄糖低于目标范围时间(TBR)、葡萄糖高于目标范围时间(TAR)、发热天数、住院时间、低血糖发生例数。结果观察组治疗后FPG、2 hPG优于对照组,差异有统计学意义(P<0.05)。观察组治疗后TIR高于对照组,差异有统计学意义(P<0.05)。观察组治疗后TBR、TAR小于对照组,差异有统计学意义(P<0.05)。观察组发热天数、住院时间均小于对照组,差异有统计学意义(P<0.05)。结论对于T2DM并PLA患者,皮下胰岛素泵方案血糖控制明显优于门冬胰岛素30注射液方案,空腹血糖达标率最显著。皮下胰岛素泵方案能显著缩短T2DM并PLA病例平均住院日及发热天数。

Objective To investigate the clinical effect of subcutaneous insulin pump on patients with type 2 diabetes mellitus complicated with liver abscess.Methods 62 patients with diabetes complicated with liver abscess admitted to Mianyang Central Hospital from July 2019 to July 2020 were analyzed and were divided into observation group(n=31)and control group(n=31)by hypoglycemia methods.Observation group was used continuous injection of insulin with subcutaneous insulin pump.Control group received insulin aspart 30 injection subcutaneous injection before three meals to control blood glucose.Fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPG),time within target range(TIR),time below target range(TBR),time above target range(TAR)and the fever days,hospital stay,and incidence of hypoglycemia of the two groups were compared.Results The FPG and 2 hPG in observation group were better than control group,and the difference was statistically significant(P<0.05).TIR of observation group was higher than control group,and the difference was statistically significant(P<0.05).After treatment,TBR and TAR in observation group were lower control group,and the difference was statistically significant(P<0.05).Fever days and hospitalization days in the observation group were less than control group,and the difference was statistically significant(P<0.05).Conclusion For patients with type 2 diabetes mellitus with liver abscess,subcutaneous insulin pump therapy is better than insulin aspart 30 injection therapy in blood glucose control,especially FPG,and significantly shorten the average hospital stay and fever days.