三苯基砷/铱催化的非活化一级碳氢键的双硼化反应合成1,1-偕二硼烷

Synthesis of 1,1-Diboron Alkanes via Diborylation of Unactivated Primary C(sp^(3))—H Bonds Enabled by AsPh_(3)/Iridium Catalysis

报道了以吡唑作为导向基,三苯基砷/铱催化的活化一级碳氢键的双硼化反应.这一方法能够兼容多种官能团,能够以中等到良好的收率实现一系列1,1-偕二硼烷类化合物的合成.同时,这一方法也能够实现克级规模的反应,所获得的硼化产物能够实现进一步的转化.

The AsPh_(3)/iridium catalyzed diborylation of unactivated primary C(sp^(3))—H bonds using pyrazoles as directing groups was disclosed.This method could tolerate a variety of functional groups,affording a vast array of 1,1-diboron alkanes in moderate to good yields.The synthetic utility of the current method on a gram-scale reaction for further functionalization was also demonstrated.