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维奈克拉联合阿扎胞苷治疗伴t(6;9)急性髓系白血病1例并文献复习 被引量:2

Venetoclax combined with azacitidine in treatment of acute myeloid leukemia with t(6;9):report of 1 case and review of literature
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摘要 目的提高对维奈克拉联合阿扎胞苷治疗伴t(6;9)急性髓系白血病(AML)的认识。方法回顾性分析宁夏医科大学总医院2020年7月收治的1例接受维奈克拉联合阿扎胞苷治疗的伴t(6;9)AML患者的临床资料,并复习相关文献。结果患者以发热、皮下结节为临床表现,结合骨髓细胞形态学、免疫学、遗传学、分子生物学检查,诊断为AML-M_(2a)伴t(6;9),基因检测提示DEK-CAN、TP53、DNMT3A、ASXL1、TET2、FLT3-ITD均阳性。患者对常规化疗无效,因合并严重肺部感染而接受维奈克拉联合阿扎胞苷治疗获得完全缓解,患者家属拒绝行异基因造血干胞移植,错过最佳治疗时机,原发病复发后最终放弃治疗。结论伴t(6;9)AML治疗难度大,预后极差,常规化疗无效时维奈克拉联合阿扎胞苷治疗达完全缓解后,桥接造血干细胞移植可作为此类患者的最佳治疗选择。
作者 胡代宏 蒋莉梅 崔丽娟 Hu Daihong;Jiang Limei;Cui Lijuan(Department of Hematology,General Hospital of Ningxia Medical University,Yinchuan 750004,China)
出处 《白血病.淋巴瘤》 CAS 2022年第5期303-305,共3页 Journal of Leukemia & Lymphoma
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