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达雷妥尤单抗治疗异基因造血干细胞移植后复发CD38阳性急性白血病2例并文献复习 被引量:1

Daratumumab in treatment of relapsed CD38-positive acute leukemia after allogeneic hematopoietic stem cell transplantation:report of 2 cases and review of literature
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摘要 目的探讨达雷妥尤单抗治疗异基因造血干细胞移植(allo-HSCT)后复发CD38阳性急性白血病患者的效果及安全性。方法回顾性分析2018年2月和9月南方医科大学南方医院收治的2例行allo-HSCT后复发CD38阳性急性白血病患者的临床资料,并进行文献复习。结果2例行allo-HSCT后复发CD38阳性急性白血病患者,经多线治疗后均未达完全缓解,予达雷妥尤单抗单药或联合化疗治疗后均获得持续微小残留病阴性,且在治疗期间均未出现严重不良反应。结论达雷妥尤单抗单药或联合化疗为allo-HSCT后复发的急性白血病患者提供了一种新的治疗手段,其安全有效,值得临床进一步探讨。
作者 胡晓婧 范志平 李章坤 赖应昌 姜义荣 Hu Xiaojing;Fan Zhiping;Li Zhangkun;Lai Yingchang;Jiang Yirong(Dapartment of Hematology,Dongguan People's Hospital,Dongguan 523000,China;Dapartment of Hematology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)
出处 《白血病.淋巴瘤》 CAS 2022年第5期307-309,共3页 Journal of Leukemia & Lymphoma
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