黄酮类化合物与肠道菌群互作研究进展

Research Progress in the Interaction between Flavonoids and Gut Microbiota

黄酮类化合物广泛存在于蔬菜和水果中,能够显著促进人体健康。肠道菌群也被证明对维持人体健康具有重要的调控作用。例如:肠道菌群紊乱会增加患炎症性肠病、肥胖和结直肠癌等慢性疾病的风险。本文综述膳食摄入的黄酮类化合物与肠道菌群相互作用的最新研究进展。黄酮类化合物通过促进益生菌的生长、抑制病原菌的繁殖、增加菌群的多样性以及促进菌群有益代谢物(如短链脂肪酸)的产生来发挥其生物学活性。肠道菌群影响膳食黄酮类化合物的生物转化和代谢模式,并通过产生肠道菌群介导的小分子活性代谢产物,提高黄酮类化合物的生物利用度,在一定程度上决定其生物学活性在体内的表达。

Flavonoids are a class of natural bioactive substances that are widely present in vegetables and fruits that have a promoting effect on human health.Gut microbiota has been shown to play an important regulatory role in maintaining human health.Disturbance of gut microbiota increases the risk of many chronic diseases,such like inflammatory bowel disease,obesity,and colorectal cancer.This article systematically reviews the updated research progress of the interaction between dietary flavonoids and gut microbiota.On the one hand,dietary flavonoids can exert their biological activities by increasing the diversity of gut microbiota,promoting the growth of probiotics,inhibiting the reproduction of pathogenic bacteria and promoting the production of some beneficial metabolites such as short-chain fatty acids.On the other hand,the gut microbiota greatly influences the biotransformation and metabolic patterns of the dietary flavonoids.By producing the small molecule bioactive metabolites mediated by gut microbiota and improving the bioavailability,the gut microbiota partially determines the biological activity of dietary flavonoids in the body.