阻塞性睡眠呼吸暂停低通气综合征与射血分数保留型心力衰竭的关系研究进展

Research progress on the relationship between obstructive sleep apnea hypopnea syndrome and heart failure with preserved ejection fraction

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种常见且尚未得到重视的慢性呼吸系统疾病,被认为是心力衰竭等多种心血管疾病的独立危险因素。研究表明,OSAHS与射血分数保留型心力衰竭(HFpEF)的发生、发展密切相关;但关于OSAHS与HFpEF之间相关的病理生理学机制尚不明确,OSAHS如何参与HFpEF的发生和发展成为目前研究的热点。基于此,本文就OSAHS的病理生理学机制、OSAHS参与HFpEF发生和发展的机制以及持续气道正压通气治疗对HFpEF的影响加以综述,旨在为早期诊断和治疗OSAHS、降低HFpEF的发病率和病死率提供参考。

Obstructive sleep apnea hypopnea syndrome(OSAHS)is a common and neglected chronic respiratory disease.It is considered as an independent risk factor for many cardiovascular diseases such as heart failure.Relevant studies have shown that OSAHS is closely related to the occurrence and development of heart failure with preserved ejection fraction(HFpEF).However,at present,the pathophysiological mechanism between OSAHS and HFpEF is not clear.Based on this,this paper reviews the pathophysiology mechanism of OSAHS,the mechanism of OSAHS involving in the occurrence and development of HFpEF,and the effects of continuous positive airway pressure treatment on HFpEF,in order to provide clinical reference for early diagnosis and treatment of OSAHS to reduce the incidence and mortality of HFpEF.