恶性肿瘤饥饿疗法研究现状

Current status of cancer starvation therapy

恶性肿瘤传统的治疗方法各有局限和弊端。近年来新兴的饥饿疗法通过阻断肿瘤的营养供应,达到“饿死”肿瘤细胞的目的。饥饿疗法的治疗策略主要包括:通过靶向抑制促血管生成因子及其受体和整合素,干预肿瘤血管生成机制,以抗肿瘤血管生成;通过栓塞和挤压血管,以阻断肿瘤血管的输血供氧功能;通过抑制线粒体的丝氨酸/甘氨酸/一碳代谢、抑制糖酵解、抑制氨基酸代谢等方式抑制肿瘤细胞代谢过程;饥饿疗法与氧化疗法、化学治疗、声动力疗法、抑制肿瘤细胞自噬等方法联合可以达到协同效果。本文从以上四个方面总结近年来肿瘤饥饿疗法的研究进展和存在的问题,以期对恶性肿瘤治疗策略的选择有所帮助。

Conventional therapies for malignant tumors have limitations and disadvantages.In recent years,the cancer starvation therapy has emerged which intends to deprive cancer cells of nutritional supply.There are several approaches to“starve”cancer cells:to intervene tumor angiogenesis by targeted inhibition of angiogenic factors or their receptors and integrins;to block the blood supply of cancer cells by embolizing or compressing blood vessels;to intervene metabolic process of cancer cells by inhibition of the signal pathways of mitochondrial serine-glycine-one earbon metabolism,glycolysis and amino acid metabolism;cancer starvation therapy can be employed with oxidation therapy,chemotherapy,sonodynamic therapy,anti-autophagy therapy or other therapies to achieve synergistic effects.This article reviews the research progress of cancer starvation therapy in recent years and discusses the existing problems.